kynurenine 3-monooxygenase | 1.14.13.9 Kynurenine 3-monooxygenase | IUPHAR Guide to IMMUNOPHARMACOLOGY

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kynurenine 3-monooxygenase

  Target has curated data in GtoImmuPdb

Target id: 2886

Nomenclature: kynurenine 3-monooxygenase

Family: 1.14.13.9 Kynurenine 3-monooxygenase

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 2 486 1q42-q44 KMO kynurenine 3-monooxygenase 1
Mouse 2 479 1 H4 Kmo kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
Rat 2 478 13q25 Kmo kynurenine 3-monooxygenase
Previous and Unofficial Names
kynurenine 3-hydroxylase | kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
Database Links
BRENDA
CATH/Gene3D
ChEMBL Target
Ensembl Gene
Entrez Gene
KEGG Enzyme
KEGG Gene
OMIM
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Enzyme Reaction
EC Number: 1.14.13.9
Description Reaction Reference
L-kynurenine + NADPH + O2 <=> 3-hydroxy-L-kynurenine + NADP(+) + H2O

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Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Parameter Reference
GSK180 Hs Inhibition 8.2 pIC50 2
pIC50 8.2 [2]
Description: Biochemical assay using human KMO expressed as a GST-fusion protein in a baculovirus expression system.
Immunopharmacology Comments
GSK180-induced inhibition of KMO prevents multiple organ failure in rodent models of acute pancreatitis which is caused by excessive alcohol consumption [2], and which is an inflammatory condition in humans for which there is no current therapy. A Phase 1 trial of GSK's clinical stage KMO inhibitor GSK3335065 in healthy subjects was terminated (see NCT03245619).
Immuno Process Associations
Immuno Process:  Cytokine production & signalling
GO Annotations:  Associated to 1 GO processes, IEA only
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GO:0071347 cellular response to interleukin-1 IEA

References

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1. Alberati-Giani D, Cesura AM, Broger C, Warren WD, Röver S, Malherbe P. (1997) Cloning and functional expression of human kynurenine 3-monooxygenase. FEBS Lett., 410 (2-3): 407-12. [PMID:9237672]

2. Mole DJ, Webster SP, Uings I, Zheng X, Binnie M, Wilson K, Hutchinson JP, Mirguet O, Walker A, Beaufils B et al.. (2016) Kynurenine-3-monooxygenase inhibition prevents multiple organ failure in rodent models of acute pancreatitis. Nat. Med., 22 (2): 202-9. [PMID:26752518]

How to cite this page

1.14.13.9 Kynurenine 3-monooxygenase: kynurenine 3-monooxygenase. Last modified on 08/02/2019. Accessed on 23/04/2019. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetoimmunopharmacology.org/GRAC/ObjectDisplayForward?objectId=2886.