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Type II PIP kinases (1-phosphatidylinositol-5-phosphate 4-kinase family)

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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Type II PIP kinases are essential for the production of the second messenger phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) by phosphorylating PtdIns(5)P [1]. This enzyme family is also known as type II PIP(5)Ks.

Enzymes

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Targets of relevance to immunopharmacology are highlighted in blue

PIP4K2A (phosphatidylinositol-5-phosphate 4-kinase type 2 alpha) C Show summary » More detailed page go icon to follow link

PIP4K2B (phosphatidylinositol-5-phosphate 4-kinase type 2 beta) C Show summary » More detailed page go icon to follow link

PIP4K2C (phosphatidylinositol-5-phosphate 4-kinase type 2 gamma) C Show summary » More detailed page go icon to follow link

References

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How to cite this family page

Database page citation:

Type II PIP kinases (1-phosphatidylinositol-5-phosphate 4-kinase family). Accessed on 25/07/2021. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=674.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators. (2019) The Concise Guide to PHARMACOLOGY 2019/20: Enzymes. Br J Pharmacol. 176 Issue S1: S297-S396.