complement factor D | Complement factor D | IUPHAR Guide to IMMUNOPHARMACOLOGY

Top ▲

complement factor D

  Target has curated data in GtoImmuPdb

Target id: 2842

Nomenclature: complement factor D

Family: Complement factor D

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 253 19p13.3 CFD complement factor D
Mouse - 259 10 C1 Cfd complement factor D (adipsin)
Rat - 263 7q11 Cfd complement factor D
Gene and Protein Information Comments
Amino acid counts are for the preproproteins.
Previous and Unofficial Names
complement factor D (adipsin)
Database Links
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
RefSeq Nucleotide
RefSeq Protein
Selected 3D Structures
Image of receptor 3D structure from RCSB PDB
Resolution:  2.3Å
Species:  Human
References:  3

Download all structure-activity data for this target as a CSV file

Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
example 373 [WO2012093101] Hs Inhibition 9.0 pIC50 1-2
pIC50 9.0 (IC50 1x10-9 M) [1-2]
Key to terms and symbols Click column headers to sort
Antibody Sp. Action Value Parameter Reference
lampalizumab Hs Binding 10.7 pKi 4
pKi 10.7 (Ki 2x10-11 M) [4]
Immunopharmacology Comments
A protease component of the alternative complement pathway; responsible for cleaving complement factor B.
Immuno Process Associations
Immuno Process:  Inflammation
GO Annotations:  Associated to 2 GO processes
GO:0006957 complement activation, alternative pathway TAS
GO:0043312 neutrophil degranulation TAS
Immuno Process:  Immune regulation
GO Annotations:  Associated to 2 GO processes
GO:0006956 complement activation TAS
GO:0006957 complement activation, alternative pathway TAS
Immuno Process:  Cellular signalling
GO Annotations:  Associated to 1 GO processes
GO:0043312 neutrophil degranulation TAS
Clinically-Relevant Mutations and Pathophysiology
Disease:  Complement factor D deficiency; CFDD
Synonyms: Factor D deficiency [OMIM: 613912]
Recurrent Neisseria infections due to factor D deficiency [Orphanet: ORPHA169467]
OMIM: 613912
Orphanet: ORPHA169467


Show »

1. Abdel-Magid AF. (2012) Factor D Inhibitors for the Treatment of AMD: Patent Highlight. ACS Med Chem Lett, 3 (10): 781-2. [PMID:24900375]

2. Altmann E, Hommel U, Lorthiois ELJ, Maibaum JK, Ostermann N, Quancard J, Randl SA, Rogel O, Simic O, Vulpetti A. (2012) Indole compounds or analogues thereof useful for the treatment of age-related macular degeneration (AMD). Patent number: WO2012093101. Assignee: Novartis Ag. Priority date: 04/01/2011. Publication date: 12/07/2012.

3. Jing H, Babu YS, Moore D, Kilpatrick JM, Liu XY, Volanakis JE, Narayana SV. (1998) Structures of native and complexed complement factor D: implications of the atypical His57 conformation and self-inhibitory loop in the regulation of specific serine protease activity. J. Mol. Biol., 282 (5): 1061-81. [PMID:9753554]

4. Loyet KM, Good J, Davancaze T, Sturgeon L, Wang X, Yang J, Le KN, Wong M, Hass PE, Campagne Mv et al.. (2014) Complement inhibition in cynomolgus monkeys by anti-factor d antigen-binding fragment for the treatment of an advanced form of dry age-related macular degeneration. J. Pharmacol. Exp. Ther., 351 (3): 527-37. [PMID:25232192]

How to cite this page Complement factor D: complement factor D. Last modified on 17/02/2017. Accessed on 03/08/2020. IUPHAR/BPS Guide to PHARMACOLOGY,