decoy receptor 3 | Tumour necrosis factor (TNF) receptor family | IUPHAR Guide to IMMUNOPHARMACOLOGY

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decoy receptor 3

  Target has curated data in GtoImmuPdb

Target id: 2322

Nomenclature: decoy receptor 3

Systematic Nomenclature: TNFRSF6B

Family: Tumour necrosis factor (TNF) receptor family

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 300 20q13.33 TNFRSF6B TNF receptor superfamily member 6b
Previous and Unofficial Names
DCR3 | decoy receptor for Fas ligand | tumor necrosis factor receptor superfamily, member 6b, decoy | tumor necrosis factor receptor superfamily member 6b
Database Links
Ensembl Gene
Entrez Gene
Human Protein Atlas
Immunopharmacology Comments
The protein product of the TNFRSF6B gene, known as decoy receptor 3 (DcR3), is a soluble endogenous receptor for three TNF family peptide ligands, LIGHT, TL1A and Fas ligand. DcR3 competes for ligand binding with death receptors. DcR3 suppresses LIGHT and FAS ligand induced apoptosis and T cell activation, and increases monocyte adhesion to endothelial cells via NF-κB activation [1]. DcR3 binding to TL1A induces angiogenesis [2]. These functions of DcR3 suggest it provides a connection between inflammation and cancer development.
Immuno Process Associations
Immuno Process:  Cytokine production & signalling
GO Annotations:  Associated to 1 GO processes
GO:0033209 tumor necrosis factor-mediated signaling pathway TAS


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1. Yang CR, Hsieh SL, Ho FM, Lin WW. (2005) Decoy receptor 3 increases monocyte adhesion to endothelial cells via NF-kappa B-dependent up-regulation of intercellular adhesion molecule-1, VCAM-1, and IL-8 expression. J. Immunol., 174 (3): 1647-56. [PMID:15661928]

2. Yang CR, Hsieh SL, Teng CM, Ho FM, Su WL, Lin WW. (2004) Soluble decoy receptor 3 induces angiogenesis by neutralization of TL1A, a cytokine belonging to tumor necrosis factor superfamily and exhibiting angiostatic action. Cancer Res., 64 (3): 1122-9. [PMID:14871847]

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