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Target has curated data in GtoImmuPdb
Target id: 2322
Nomenclature: decoy receptor 3
Systematic Nomenclature: TNFRSF6B
Gene and Protein Information | ||||||
Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
Human | - | 300 | 20q13.33 | TNFRSF6B | TNF receptor superfamily member 6b |
Previous and Unofficial Names |
DCR3 | decoy receptor for Fas ligand | tumor necrosis factor receptor superfamily, member 6b, decoy | tumor necrosis factor receptor superfamily member 6b |
Database Links | |
Alphafold | O95407 (Hs) |
Ensembl Gene | ENSG00000243509 (Hs) |
Entrez Gene | 8771 (Hs) |
Human Protein Atlas | ENSG00000243509 (Hs) |
KEGG Gene | hsa:8771 (Hs) |
OMIM | 603361 (Hs) |
Pharos | O95407 (Hs) |
UniProtKB | O95407 (Hs) |
Wikipedia | TNFRSF6B (Hs) |
Natural/Endogenous Ligands |
LIGHT {Sp: Human} |
Immunopharmacology Comments |
The protein product of the TNFRSF6B gene, known as decoy receptor 3 (DcR3), is a soluble endogenous receptor for three TNF family peptide ligands, LIGHT, TL1A and Fas ligand. DcR3 competes for ligand binding with death receptors. DcR3 suppresses LIGHT and FAS ligand induced apoptosis and T cell activation, and increases monocyte adhesion to endothelial cells via NF-κB activation [1]. DcR3 binding to TL1A induces angiogenesis [2]. These functions of DcR3 suggest it provides a connection between inflammation and cancer development. |
Immuno Process Associations | ||
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1. Yang CR, Hsieh SL, Ho FM, Lin WW. (2005) Decoy receptor 3 increases monocyte adhesion to endothelial cells via NF-kappa B-dependent up-regulation of intercellular adhesion molecule-1, VCAM-1, and IL-8 expression. J Immunol, 174 (3): 1647-56. [PMID:15661928]
2. Yang CR, Hsieh SL, Teng CM, Ho FM, Su WL, Lin WW. (2004) Soluble decoy receptor 3 induces angiogenesis by neutralization of TL1A, a cytokine belonging to tumor necrosis factor superfamily and exhibiting angiostatic action. Cancer Res, 64 (3): 1122-9. [PMID:14871847]