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cyclin dependent kinase 11B

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Target not currently curated in GtoImmuPdb

Target id: 1964

Nomenclature: cyclin dependent kinase 11B

Abbreviated Name: CDK11B

Family: PITSLRE subfamily

Contents:

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 795 1p36.33 CDK11B cyclin dependent kinase 11B
Mouse - 784 4 86.73 cM Cdk11b cyclin dependent kinase 11B
Rat - 436 5q36 Cdk11b cyclin-dependent kinase 11B
Previous and Unofficial Names Click here for help
cell division protein kinase 11 | CDC2L1 | CDK11-p110 | CDK11-p46 | CDK11-p58 | cell division cycle 2-like protein kinase 1 | PITSLRE serine/threonine-protein kinase CDC2L1 | PITSLRE serine/threonine-protein kinase CDC2L1CDK11-p110
Database Links Click here for help
Alphafold P21127 (Hs), P24788 (Mm), P46892 (Rn)
BRENDA 2.7.11.22
ChEMBL Target CHEMBL5808 (Hs)
Ensembl Gene ENSG00000248333 (Hs), ENSMUSG00000029062 (Mm), ENSRNOG00000017213 (Rn)
Entrez Gene 984 (Hs), 12537 (Mm), 252879 (Rn)
Human Protein Atlas ENSG00000248333 (Hs)
KEGG Enzyme 2.7.11.22
KEGG Gene hsa:984 (Hs), mmu:12537 (Mm), rno:252879 (Rn)
OMIM 176873 (Hs)
Pharos P21127 (Hs)
RefSeq Nucleotide NM_033486 (Hs), NM_007661 (Mm), NM_145766 (Rn)
RefSeq Protein NP_277021 (Hs), NP_031687 (Mm), NP_665709 (Rn)
UniProtKB P21127 (Hs), P24788 (Mm), P46892 (Rn)
Wikipedia CDK11B (Hs)
Enzyme Reaction Click here for help
EC Number: 2.7.11.22
DiscoveRx KINOMEscan® screen Click here for help
A screen of 72 inhibitors against 456 human kinases. Quantitative data were derived using DiscoveRx KINOMEscan® platform.
http://www.discoverx.com/services/drug-discovery-development-services/kinase-profiling/kinomescan
Reference: 1-2
Key to terms and symbols Click column headers to sort
Target used in screen: CDC2L1
Ligand Sp. Type Action Value Parameter
AT-7519 Small molecule or natural product Ligand has a PDB structure Hs Inhibitor Inhibition 8.1 pKd
BMS-387032 Small molecule or natural product Ligand has a PDB structure Hs Inhibitor Inhibition 7.0 pKd
tozasertib Small molecule or natural product Ligand has a PDB structure Hs Inhibitor Inhibition 6.5 pKd
BMS-345541 Small molecule or natural product Immunopharmacology Ligand Hs Inhibitor Inhibition 6.4 pKd
foretinib Small molecule or natural product Ligand has a PDB structure Hs Inhibitor Inhibition 6.2 pKd
crizotinib Small molecule or natural product Approved drug Ligand has a PDB structure Immunopharmacology Ligand Hs Inhibitor Inhibition 6.1 pKd
barasertib-hQPA Small molecule or natural product Ligand has a PDB structure Hs Inhibitor Inhibition 5.9 pKd
linifanib Small molecule or natural product Hs Inhibitor Inhibition 5.9 pKd
AST-487 Small molecule or natural product Hs Inhibitor Inhibition 5.8 pKd
pazopanib Small molecule or natural product Approved drug Hs Inhibitor Inhibition 5.7 pKd
Displaying the top 10 most potent ligands  View all ligands in screen »

References

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1. Davis MI, Hunt JP, Herrgard S, Ciceri P, Wodicka LM, Pallares G, Hocker M, Treiber DK, Zarrinkar PP. (2011) Comprehensive analysis of kinase inhibitor selectivity. Nat Biotechnol, 29 (11): 1046-51. [PMID:22037378]

2. Wodicka LM, Ciceri P, Davis MI, Hunt JP, Floyd M, Salerno S, Hua XH, Ford JM, Armstrong RC, Zarrinkar PP et al.. (2010) Activation state-dependent binding of small molecule kinase inhibitors: structural insights from biochemistry. Chem Biol, 17 (11): 1241-9. [PMID:21095574]

How to cite this page

PITSLRE subfamily: cyclin dependent kinase 11B. Last modified on 19/12/2013. Accessed on 06/12/2024. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetoimmunopharmacology.org/GRAC/ObjectDisplayForward?objectId=1964.