pazopanib   Click here for help

GtoPdb Ligand ID: 5698

Synonyms: GW 786034 | indazolylpyrimidine 13 [4] | Votrient®
Approved drug
pazopanib is an approved drug (FDA (2009), EMA (2010))
Compound class: Synthetic organic
Comment: Pazopanib is a Type-1 kinase inhibitor. Its discovery is reported in [5]. It targets multiple receptor tyrosine kinases (VEGFR1, VEGFR2, VEGFR3, PDGFRβ, FGFR1, Kit and CSF1R).
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 8
Hydrogen bond donors 2
Rotatable bonds 5
Topological polar surface area 127.41
Molecular weight 437.16
XLogP 3.34
No. Lipinski's rules broken 0
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Canonical SMILES CN(c1ccc2c(c1)nn(c2C)C)c1ccnc(n1)Nc1ccc(c(c1)S(=O)(=O)N)C
Isomeric SMILES CN(c1ccc2c(c1)nn(c2C)C)c1ccnc(n1)Nc1ccc(c(c1)S(=O)(=O)N)C
InChI InChI=1S/C21H23N7O2S/c1-13-5-6-15(11-19(13)31(22,29)30)24-21-23-10-9-20(25-21)27(3)16-7-8-17-14(2)28(4)26-18(17)12-16/h5-12H,1-4H3,(H2,22,29,30)(H,23,24,25)
Classification Click here for help
Compound class Synthetic organic
Approved drug? Yes (FDA (2009), EMA (2010))
IUPAC Name Click here for help
International Nonproprietary Names Click here for help
INN number INN
8681 pazopanib
Synonyms Click here for help
GW 786034 | indazolylpyrimidine 13 [4] | Votrient®
Database Links Click here for help
Specialist databases
Reactome Drug Reactome logo R-ALL-9616920
Reactome Reaction Reactome logo R-HSA-9693978, R-HSA-2029992, R-HSA-2077424, R-HSA-9674427, R-HSA-9674093
Other databases
CAS Registry No. 444731-52-6
ChEMBL Ligand CHEMBL477772
DrugCentral Ligand 4118
GtoPdb PubChem SID 178102325
PubChem CID 10113978
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UniChem Compound Search for chemical match using the InChIKey CUIHSIWYWATEQL-UHFFFAOYSA-N
UniChem Connectivity Search for chemical match using the InChIKey CUIHSIWYWATEQL-UHFFFAOYSA-N
Wikipedia Pazopanib