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cyclin dependent kinase 11A

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Target not currently curated in GtoImmuPdb

Target id: 1963

Nomenclature: cyclin dependent kinase 11A

Abbreviated Name: CDK11A

Family: PITSLRE subfamily

Contents:

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 783 1p36.33 CDK11A cyclin dependent kinase 11A
Previous and Unofficial Names Click here for help
CDC2L2 | CDC2L3 | CDK11-p110 | CDK11-p46 | CDK11-p58 | cell division cycle 2-like 2 (PITSLRE proteins) | Cell division cycle 2-like protein kinase 2 | Cell division protein kinase 11A | PITSLRE serine/threonine-protein kinase CDC2L2 | cyclin-dependent kinase 11A
Database Links Click here for help
Alphafold Q9UQ88 (Hs)
BRENDA 2.7.11.22
ChEMBL Target CHEMBL5416 (Hs)
Ensembl Gene ENSG00000008128 (Hs)
Entrez Gene 728642 (Hs)
Human Protein Atlas ENSG00000008128 (Hs)
KEGG Enzyme 2.7.11.22
KEGG Gene hsa:728642 (Hs)
OMIM 116951 (Hs)
Pharos Q9UQ88 (Hs)
RefSeq Nucleotide NM_024011 (Hs)
RefSeq Protein NP_076916 (Hs)
UniProtKB Q9UQ88 (Hs)
Wikipedia CDK11A (Hs)
Enzyme Reaction Click here for help
EC Number: 2.7.11.22
DiscoveRx KINOMEscan® screen Click here for help
A screen of 72 inhibitors against 456 human kinases. Quantitative data were derived using DiscoveRx KINOMEscan® platform.
http://www.discoverx.com/services/drug-discovery-development-services/kinase-profiling/kinomescan
Reference: 1-2
Key to terms and symbols Click column headers to sort
Target used in screen: CDC2L2
Ligand Sp. Type Action Value Parameter
AT-7519 Small molecule or natural product Ligand has a PDB structure Hs Inhibitor Inhibition 8.3 pKd
BMS-387032 Small molecule or natural product Ligand has a PDB structure Hs Inhibitor Inhibition 7.3 pKd
tozasertib Small molecule or natural product Ligand has a PDB structure Hs Inhibitor Inhibition 6.6 pKd
BMS-345541 Small molecule or natural product Immunopharmacology Ligand Hs Inhibitor Inhibition 6.4 pKd
crizotinib Small molecule or natural product Approved drug Ligand has a PDB structure Immunopharmacology Ligand Hs Inhibitor Inhibition 6.4 pKd
foretinib Small molecule or natural product Ligand has a PDB structure Hs Inhibitor Inhibition 6.3 pKd
barasertib-hQPA Small molecule or natural product Ligand has a PDB structure Hs Inhibitor Inhibition 6.0 pKd
AST-487 Small molecule or natural product Hs Inhibitor Inhibition 6.0 pKd
linifanib Small molecule or natural product Hs Inhibitor Inhibition 5.9 pKd
pazopanib Small molecule or natural product Approved drug Hs Inhibitor Inhibition 5.9 pKd
Displaying the top 10 most potent ligands  View all ligands in screen »

References

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1. Davis MI, Hunt JP, Herrgard S, Ciceri P, Wodicka LM, Pallares G, Hocker M, Treiber DK, Zarrinkar PP. (2011) Comprehensive analysis of kinase inhibitor selectivity. Nat Biotechnol, 29 (11): 1046-51. [PMID:22037378]

2. Wodicka LM, Ciceri P, Davis MI, Hunt JP, Floyd M, Salerno S, Hua XH, Ford JM, Armstrong RC, Zarrinkar PP et al.. (2010) Activation state-dependent binding of small molecule kinase inhibitors: structural insights from biochemistry. Chem Biol, 17 (11): 1241-9. [PMID:21095574]

How to cite this page

PITSLRE subfamily: cyclin dependent kinase 11A. Last modified on 20/03/2013. Accessed on 06/12/2024. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetoimmunopharmacology.org/GRAC/ObjectDisplayForward?objectId=1963.