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Immunopharmacology Ligand  Target has curated data in GtoImmuPdb

Target id: 1753

Nomenclature: TLR3

Family: Toll-like receptor family

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 904 4q35.1 TLR3 toll like receptor 3
Mouse 1 905 8 B1.1 Tlr3 toll-like receptor 3
Rat - - 16q11 Tlr3 toll-like receptor 3
Previous and Unofficial Names Click here for help
toll-like receptor 3 | CD283 | IIAE2
Database Links Click here for help
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
Activator Comments
Poly(I:C) activation of TLR3 is assessed by its ability to induce cytokine production or activation of NF-κB and mitogen-activated protein (MAP) kinases [1].
Immunopharmacology Comments
TLR3 is an endosomal anti-viral receptor [2], with potent pro-inflammatory actions (e.g. induction of Type I IFN and pro-inflammatory cytokines, including IL-6, TNF, IL-17, IL-21, IP-10 and RANTES). Innate Pharma are developing IPH33 as an anti-TLR3 anti-inflammatory biologic, which acts upstream relative to current therapies such as anti-TNF and anti-IL-6 mAbs and small molecule JAK inhibitors.
Immuno Process Associations
Immuno Process:  Inflammation
Immuno Process:  Immune regulation
Immuno Process:  Immune system development
Immuno Process:  Cytokine production & signalling
Immuno Process:  Chemotaxis & migration
Immuno Process:  Cellular signalling
Clinically-Relevant Mutations and Pathophysiology Click here for help
Disease:  Cervical cancer
Disease Ontology: DOID:4362
OMIM: 603956
Disease:  Colorectal cancer
Disease Ontology: DOID:9256
OMIM: 114500
Disease:  Herpes simplex encephalitis, susceptibility to, 2
Synonyms: Herpes simplex virus encephalitis [Disease Ontology: DOID:0050181]
Herpetic encephalitis [Orphanet: ORPHA1930]
Disease Ontology: DOID:0050181
OMIM: 613002
Orphanet: ORPHA1930
Disease:  Human immunodeficiency virus type 1, susceptibility to
Synonyms: Human immunodeficiency virus infectious disease [Disease Ontology: DOID:526]
Disease Ontology: DOID:526
OMIM: 609423
Orphanet: ORPHA319269
Disease:  Macular degeneration, age-related, 1; ARMD1
Synonyms: Age-related macular degeneration [Orphanet: ORPHA279] [Disease Ontology: DOID:10871]
Disease Ontology: DOID:10871
OMIM: 603075
Orphanet: ORPHA279
Disease:  Stevens-Johnson syndrome
Synonyms: Severe cutaneous adverse reaction, susceptibility to [OMIM: 608579]
Disease Ontology: DOID:0050426
OMIM: 608579
Orphanet: ORPHA36426


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1. Alexopoulou L, Holt AC, Medzhitov R, Flavell RA. (2001) Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3. Nature, 413 (6857): 732-8. [PMID:11607032]

2. Uematsu S, Akira S. (2008) Toll-Like receptors (TLRs) and their ligands. Handb Exp Pharmacol, (183): 1-20. [PMID:18071652]


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