TLR3 | Toll-like receptor family | IUPHAR Guide to IMMUNOPHARMACOLOGY

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TLR3

  Target has curated data in GtoImmuPdb

Target id: 1753

Nomenclature: TLR3

Family: Toll-like receptor family

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 881 4q35.1 TLR3 toll like receptor 3
Mouse - 880 8 25.31 cM Tlr3 toll-like receptor 3
Rat - - 16q11 Tlr3 toll-like receptor 3
Previous and Unofficial Names
toll-like receptor 3 | CD283 | IIAE2
Database Links
CATH/Gene3D
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
OMIM
UniProtKB
Wikipedia
Activator Comments
Poly(I:C) activation of TLR3 is assessed by its ability to induce cytokine production or activation of NF-κB and mitogen-activated protein (MAP) kinases [1].
Immunopharmacology Comments
TLR3 is an endosomal anti-viral receptor [2], with potent pro-inflammatory actions (e.g. induction of Type I IFN and pro-inflammatory cytokines, including IL-6, TNF, IL-17, IL-21, IP-10 and RANTES). Innate Pharma are developing IPH33 as an anti-TLR3 anti-inflammatory biologic, which acts upstream relative to current therapies such as anti-TNF and anti-IL-6 mAbs and small molecule JAK inhibitors.
Immuno Process Associations
Immuno Process:  Inflammation
GO Annotations:  Associated to 11 GO processes
GO:0002224 toll-like receptor signaling pathway TAS
GO:0002756 MyD88-independent toll-like receptor signaling pathway TAS
GO:0006954 inflammatory response IBA
GO:0034123 positive regulation of toll-like receptor signaling pathway IDA
GO:0034128 negative regulation of MyD88-independent toll-like receptor signaling pathway TAS
GO:0034138 toll-like receptor 3 signaling pathway TAS
GO:0035666 TRIF-dependent toll-like receptor signaling pathway TAS
GO:0045087 innate immune response TAS
GO:0050729 positive regulation of inflammatory response IC
click arrow to show/hide IEA associations
GO:0001774 microglial cell activation IEA
GO:0071346 cellular response to interferon-gamma IEA
Immuno Process:  Immune regulation
GO Annotations:  Associated to 9 GO processes
GO:0002224 toll-like receptor signaling pathway TAS
GO:0002756 MyD88-independent toll-like receptor signaling pathway TAS
GO:0034123 positive regulation of toll-like receptor signaling pathway IDA
GO:0034128 negative regulation of MyD88-independent toll-like receptor signaling pathway TAS
GO:0034138 toll-like receptor 3 signaling pathway TAS
GO:0035666 TRIF-dependent toll-like receptor signaling pathway TAS
GO:0045671 negative regulation of osteoclast differentiation NAS
GO:0050729 positive regulation of inflammatory response IC
click arrow to show/hide IEA associations
GO:0002730 regulation of dendritic cell cytokine production IEA
Immuno Process:  Immune system development
GO Annotations:  Associated to 1 GO processes
GO:0045671 negative regulation of osteoclast differentiation NAS
Immuno Process:  Cytokine production & signalling
GO Annotations:  Associated to 15 GO processes
GO:0032481 positive regulation of type I interferon production IDA
GO:0032722 positive regulation of chemokine production IDA
GO:0032728 positive regulation of interferon-beta production ISS
GO:0032735 positive regulation of interleukin-12 production ISS
GO:0032755 positive regulation of interleukin-6 production IDA
GO:0032757 positive regulation of interleukin-8 production IDA
GO:0032760 positive regulation of tumor necrosis factor production ISS
GO:0045078 positive regulation of interferon-gamma biosynthetic process IDA
GO:0045356 positive regulation of interferon-alpha biosynthetic process IDA
GO:0045359 positive regulation of interferon-beta biosynthetic process IDA
click arrow to show/hide IEA associations
GO:0002730 regulation of dendritic cell cytokine production IEA
GO:0034346 positive regulation of type III interferon production IEA
GO:0035458 cellular response to interferon-beta IEA
GO:0045080 positive regulation of chemokine biosynthetic process IEA
GO:0071346 cellular response to interferon-gamma IEA
Immuno Process:  Chemotaxis & migration
GO Annotations:  Associated to 2 GO processes
GO:0032722 positive regulation of chemokine production IDA
click arrow to show/hide IEA associations
GO:0045080 positive regulation of chemokine biosynthetic process IEA
Immuno Process:  Cellular signalling
GO Annotations:  Associated to 7 GO processes
GO:0002224 toll-like receptor signaling pathway TAS
GO:0002756 MyD88-independent toll-like receptor signaling pathway TAS
GO:0034123 positive regulation of toll-like receptor signaling pathway IDA
GO:0034128 negative regulation of MyD88-independent toll-like receptor signaling pathway TAS
GO:0034138 toll-like receptor 3 signaling pathway TAS
GO:0035666 TRIF-dependent toll-like receptor signaling pathway TAS
click arrow to show/hide IEA associations
GO:0001774 microglial cell activation IEA
Clinically-Relevant Mutations and Pathophysiology
Disease:  Cervical cancer
Disease Ontology: DOID:4362
OMIM: 603956
Disease:  Colorectal cancer
Disease Ontology: DOID:9256
OMIM: 114500
Disease:  Herpes simplex encephalitis, susceptibility to, 2
Synonyms: Herpes simplex virus encephalitis [Disease Ontology: DOID:0050181]
Herpetic encephalitis [Orphanet: ORPHA1930]
Disease Ontology: DOID:0050181
OMIM: 613002
Orphanet: ORPHA1930
Disease:  Human immunodeficiency virus type 1, susceptibility to
Synonyms: Human immunodeficiency virus infectious disease [Disease Ontology: DOID:526]
Disease Ontology: DOID:526
OMIM: 609423
Orphanet: ORPHA319269
Disease:  Macular degeneration, age-related, 1; ARMD1
Synonyms: Age-related macular degeneration [Orphanet: ORPHA279] [Disease Ontology: DOID:10871]
Disease Ontology: DOID:10871
OMIM: 603075
Orphanet: ORPHA279
Disease:  Stevens-Johnson syndrome
Synonyms: Severe cutaneous adverse reaction, susceptibility to [OMIM: 608579]
Disease Ontology: DOID:0050426
OMIM: 608579
Orphanet: ORPHA36426

References

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1. Alexopoulou L, Holt AC, Medzhitov R, Flavell RA. (2001) Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3. Nature, 413 (6857): 732-8. [PMID:11607032]

2. Uematsu S, Akira S. (2008) Toll-Like receptors (TLRs) and their ligands. Handb Exp Pharmacol, (183): 1-20. [PMID:18071652]

Contributors

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