Interleukin-17 receptor D | IL-17 receptor family | IUPHAR Guide to IMMUNOPHARMACOLOGY

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Interleukin-17 receptor D

  Target has curated data in GtoImmuPdb

Target id: 1741

Nomenclature: Interleukin-17 receptor D

Family: IL-17 receptor family

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 739 03p14.3 IL17RD interleukin 17 receptor D
Mouse 1 738 Il17rd interleukin 17 receptor D
Rat - - Il17rd interleukin 17 receptor D
Previous and Unofficial Names
Database Links
Ensembl Gene
Entrez Gene
Human Protein Atlas
Immunopharmacology Comments
IL17RD acts as an inhibitor of proinflammatory cytokine signaling (by limiting NF-κB translocation to the nucleus) [1], and has been reported as a feedback antagonist of receptor tyrosine kinase (RTK) signaling [3], and as a tumor suppressor gene [2,4].
Immuno Process Associations
Immuno Process:  Cytokine production & signalling
GO Annotations:  Associated to 1 GO processes
GO:0030368 interleukin-17 receptor activity IBA


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1. Fuchs Y, Brunwasser M, Haif S, Haddad J, Shneyer B, Goldshmidt-Tran O, Korsensky L, Abed M, Zisman-Rozen S, Koren L et al.. (2012) Sef is an inhibitor of proinflammatory cytokine signaling, acting by cytoplasmic sequestration of NF-κB. Dev. Cell, 23 (3): 611-23. [PMID:22975329]

2. Murphy T, Darby S, Mathers ME, Gnanapragasam VJ. (2010) Evidence for distinct alterations in the FGF axis in prostate cancer progression to an aggressive clinical phenotype. J. Pathol., 220 (4): 452-60. [PMID:19960500]

3. Ron D, Fuchs Y, Chorev DS. (2008) Know thy Sef: a novel class of feedback antagonists of receptor tyrosine kinase signaling. Int. J. Biochem. Cell Biol., 40 (10): 2040-52. [PMID:18450498]

4. Zisman-Rozen S, Fink D, Ben-Izhak O, Fuchs Y, Brodski A, Kraus MH, Bejar J, Ron D. (2007) Downregulation of Sef, an inhibitor of receptor tyrosine kinase signaling, is common to a variety of human carcinomas. Oncogene, 26 (41): 6093-8. [PMID:17420726]

How to cite this page

IL-17 receptor family: Interleukin-17 receptor D. Last modified on 07/04/2017. Accessed on 06/07/2020. IUPHAR/BPS Guide to PHARMACOLOGY,