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Target has curated data in GtoImmuPdb
Target id: 1736
Nomenclature: Interleukin-1 receptor-like 2
Quaternary Structure: Complexes |
Interleukin-36 receptor |
Gene and Protein Information | ||||||
Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
Human | 1 | 575 | 2q12.1 | IL1RL2 | interleukin 1 receptor like 2 | |
Mouse | 1 | 574 | 1 B | Il1rl2 | interleukin 1 receptor-like 2 | |
Rat | 1 | 561 | 9q22 | Il1rl2 | interleukin 1 receptor-like 2 |
Previous and Unofficial Names |
IL1RRP2 | interleukin-1 receptor-related protein 2 |
Database Links | |
Alphafold | Q9HB29 (Hs), Q9ERS7 (Mm), Q62929 (Rn) |
CATH/Gene3D | 2.60.40.10, 3.40.50.10140 |
ChEMBL Target | CHEMBL4665591 (Hs) |
Ensembl Gene | ENSG00000115598 (Hs), ENSMUSG00000070942 (Mm), ENSRNOG00000014683 (Rn) |
Entrez Gene | 8808 (Hs), 107527 (Mm), 171106 (Rn) |
Human Protein Atlas | ENSG00000115598 (Hs) |
KEGG Gene | hsa:8808 (Hs), mmu:107527 (Mm), rno:171106 (Rn) |
OMIM | 604512 (Hs) |
Pharos | Q9HB29 (Hs) |
UniProtKB | Q9HB29 (Hs), Q9ERS7 (Mm), Q62929 (Rn) |
Wikipedia | IL1RL2 (Hs) |
Download all structure-activity data for this target as a CSV file
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Immunopharmacology Comments |
Interleukin-1 receptor-like 2 is one of the subunits of the functional receptor for IL-36. An antibody that mimics IL-36RA's antagonist activity at the IL-36 receptor (MAB92) has been described [2]. MAB92 inhibits proinflammatory cytokine production in primary human keratinocytes and dermal fibroblasts in vitro. Such IL-36 antagonist antibodies are predicted to present a novel therapeutic mechanism for the treatment of epithelial cell-mediated inflammation, in particular for DITRA (deficiency of IL-36 receptor antagonist) type syndromes caused by functionally inactivating mutations in IL-36RA which leave the pro-inflammatory activity of IL-36 receptor ligands unopposed. |
Immuno Process Associations | ||
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1. Brown SE, Canada K, Chlewicki L, Howell M, Mennerich D, Woska JR. (2015) Anti IL-36R antibodies. Patent number: US9023995B2. Assignee: Boehringer Ingelheim International GmbH. Priority date: 16/11/2011. Publication date: 05/05/2015.
2. Ganesan R, Raymond EL, Mennerich D, Woska Jr JR, Caviness G, Grimaldi C, Ahlberg J, Perez R, Roberts S, Yang D et al.. (2017) Generation and functional characterization of anti-human and anti-mouse IL-36R antagonist monoclonal antibodies. MAbs, 9 (7): 1143-1154. [PMID:28726542]
Immunoglobulin-like family of IL-1 receptors: Interleukin-1 receptor-like 2. Last modified on 05/09/2022. Accessed on 04/11/2024. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetoimmunopharmacology.org/GRAC/ObjectDisplayForward?objectId=1736.