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Interleukin-1 receptor-like 2

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Immunopharmacology Ligand  Target has curated data in GtoImmuPdb

Target id: 1736

Nomenclature: Interleukin-1 receptor-like 2

Family: Immunoglobulin-like family of IL-1 receptors

Quaternary Structure: Complexes
Interleukin-36 receptor
Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 575 2q12.1 IL1RL2 interleukin 1 receptor like 2
Mouse 1 574 1 B Il1rl2 interleukin 1 receptor-like 2
Rat 1 561 9q22 Il1rl2 interleukin 1 receptor-like 2
Previous and Unofficial Names Click here for help
IL1RRP2 | interleukin-1 receptor-related protein 2
Database Links Click here for help
Alphafold
CATH/Gene3D
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
OMIM
Pharos
UniProtKB
Wikipedia

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Antibodies
Key to terms and symbols Click column headers to sort
Antibody Sp. Action Value Parameter Reference
MAB92 Peptide Primary target of this compound Immunopharmacology Ligand Hs Antagonist 10.6 pKd 2
pKd 10.6 (Kd 2x10-11 M) [2]
Description: Binding affinity for recombinant hIL-36R by SPR
spesolimab Peptide Approved drug Immunopharmacology Ligand Hs Binding ~10.5 pKd 1
pKd ~10.5 (Kd ~3x10-11 M) [1]
Immunopharmacology Comments
Interleukin-1 receptor-like 2 is one of the subunits of the functional receptor for IL-36.

An antibody that mimics IL-36RA's antagonist activity at the IL-36 receptor (MAB92) has been described [2]. MAB92 inhibits proinflammatory cytokine production in primary human keratinocytes and dermal fibroblasts in vitro. Such IL-36 antagonist antibodies are predicted to present a novel therapeutic mechanism for the treatment of epithelial cell-mediated inflammation, in particular for DITRA (deficiency of IL-36 receptor antagonist) type syndromes caused by functionally inactivating mutations in IL-36RA which leave the pro-inflammatory activity of IL-36 receptor ligands unopposed.
Immuno Process Associations
Immuno Process:  Cytokine production & signalling
Immuno Process:  Inflammation
Immuno Process:  T cell (activation)
Immuno Process:  Immune regulation
Immuno Process:  Immune system development
Immuno Process:  Chemotaxis & migration
Immuno Process:  Cellular signalling

References

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1. Brown SE, Canada K, Chlewicki L, Howell M, Mennerich D, Woska JR. (2015) Anti IL-36R antibodies. Patent number: US9023995B2. Assignee: Boehringer Ingelheim International GmbH. Priority date: 16/11/2011. Publication date: 05/05/2015.

2. Ganesan R, Raymond EL, Mennerich D, Woska Jr JR, Caviness G, Grimaldi C, Ahlberg J, Perez R, Roberts S, Yang D et al.. (2017) Generation and functional characterization of anti-human and anti-mouse IL-36R antagonist monoclonal antibodies. MAbs, 9 (7): 1143-1154. [PMID:28726542]

How to cite this page

Immunoglobulin-like family of IL-1 receptors: Interleukin-1 receptor-like 2. Last modified on 05/09/2022. Accessed on 21/02/2024. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetoimmunopharmacology.org/GRAC/ObjectDisplayForward?objectId=1736.