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Immunoglobulin-like family of IL-1 receptors C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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The immunoglobulin-like family of IL-1 receptors are heterodimeric receptors made up of a cognate receptor subunit and an IL-1 receptor accessory protein, IL1RAP (Q9NPH3, also known as C3orf13, IL-1RAcP, IL1R3). They are characterised by extracellular immunoglobulin-like domains and an intracellular Toll/Interleukin-1R (TIR) domain.

Receptors

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Targets of relevance to immunopharmacology are highlighted in blue

Complexes

Interleukin-1 receptor, type I C Show summary » More detailed page go icon to follow link

Interleukin-33 receptor C Show summary » More detailed page go icon to follow link

Interleukin-36 receptor C Show summary » More detailed page go icon to follow link

Interleukin-1 receptor, type II C Show summary » More detailed page go icon to follow link

Interleukin-18 receptor C Show summary » More detailed page go icon to follow link

Receptors and Subunits

Interleukin 1 receptor, type I C Show summary » More detailed page go icon to follow link

Interleukin 1 receptor, type II C Show summary » More detailed page go icon to follow link

Interleukin-1 receptor-like 1 C Show summary » More detailed page go icon to follow link

Interleukin-1 receptor-like 2 C Show summary » More detailed page go icon to follow link

Interleukin-18 receptor 1 C Show summary » More detailed page go icon to follow link

single Ig and TIR domain containing / IL-1R8 Show summary » More detailed page go icon to follow link

Accessory Proteins

IL-1 receptor accessory protein Show summary » More detailed page go icon to follow link

IL-18 receptor accessory protein Show summary » More detailed page go icon to follow link

Further reading

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References

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How to cite this family page

Database page citation:

Immunoglobulin-like family of IL-1 receptors. Accessed on 10/12/2024. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=312.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Catalytic receptors. Br J Pharmacol. 180 Suppl 2:S241-288.