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Interleukin 10 receptor, α subunit

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Immunopharmacology Ligand  Target has curated data in GtoImmuPdb

Target id: 1727

Nomenclature: Interleukin 10 receptor, α subunit

Family: IL-10 receptor family

Contents:

Quaternary Structure: Complexes
Interleukin-10 receptor
Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 578 11q23.3 IL10RA interleukin 10 receptor subunit alpha
Mouse 1 575 9 24.84 cM Il10ra interleukin 10 receptor, alpha
Rat - - Il10ra interleukin 10 receptor subunit alpha
Previous and Unofficial Names Click here for help
interleukin 10 receptor | CD210 | Interleukin-10 α | interleukin 10 receptor, alpha
Database Links Click here for help
Alphafold Q13651 (Hs), Q61727 (Mm)
CATH/Gene3D 2.60.40.10
ChEMBL Target CHEMBL4804254 (Hs)
Ensembl Gene ENSG00000110324 (Hs), ENSMUSG00000032089 (Mm), ENSRNOG00000016308 (Rn)
Entrez Gene 3587 (Hs), 16154 (Mm), 117539 (Rn)
Human Protein Atlas ENSG00000110324 (Hs)
KEGG Gene hsa:3587 (Hs), mmu:16154 (Mm), rno:117539 (Rn)
OMIM 146933 (Hs)
Pharos Q13651 (Hs)
UniProtKB Q13651 (Hs), Q61727 (Mm)
Wikipedia IL10RA (Hs)

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Agonists
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Ligand Sp. Action Value Parameter Reference
IL-10 {Sp: Human} Peptide Click here for species-specific activity table Immunopharmacology Ligand Hs Agonist 9.7 – 10.3 pEC50 1
⤷ pEC50 9.7 – 10.3 (EC50 2x10-10 – 5x10-11 M) [1]
Immunopharmacology Comments
Interleukin 10 receptor, α subunit is a component of the functional IL-10 receptor heterodimer.

References

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1. Mosser DM, Zhang X. (2008) Interleukin-10: new perspectives on an old cytokine. Immunol Rev, 226: 205-18. [PMID:19161426]

How to cite this page

IL-10 receptor family: Interleukin 10 receptor, α subunit. Last modified on 11/04/2017. Accessed on 01/11/2025. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetoimmunopharmacology.org/GRAC/ObjectDisplayForward?objectId=1727.