IL-10 receptor family | Catalytic receptors | IUPHAR/BPS Guide to IMMUNOPHARMACOLOGY

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IL-10 receptor family C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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The IL-10 family of receptors are heterodimeric combinations of family members: IL10RA/IL10RB responds to IL-10; IL20RA/IL20RB responds to IL-19, IL-20 and IL-24; IL22RA1/IL20RB responds to IL-20 and IL-24; IL22RA1/IL10RB responds to IL-22; IFNLR1(previouly known as IL28RA)/IL10RB responds to IFN-λ1, -λ2 and -λ3 (previouly known as IL-29, IL-28A and IL-28B respectively).

Receptors

Targets of relevance to immunopharmacology are highlighted in blue

Complexes

Interleukin-10 receptor C Show summary »« Hide summary More detailed page go icon to follow link

Interleukin-20 receptor C Show summary »« Hide summary More detailed page go icon to follow link

Interleukin-22α1/20β heteromer C Show summary »« Hide summary More detailed page go icon to follow link

Interleukin-22α1/10β heteromer C Show summary »« Hide summary More detailed page go icon to follow link

Interferon-λ receptor 1 C Show summary »« Hide summary More detailed page go icon to follow link

Receptors and Subunits

Interleukin-22 receptor α2 C Show summary »« Hide summary More detailed page go icon to follow link

Target Id	1732
Nomenclature	Interleukin-22 receptor α2
Previous and unofficial names	CRF2-S1 \| cytokine receptor family II soluble 1 \| IL-22 receptor subunit alpha-2 \| interleukin-22-binding protein \| IL-22BP \| interleukin 22 receptor, alpha 2 \| interleukin 22 receptor
Genes	IL22RA2 (Hs), Il22ra2 (Mm), Il22ra2 (Rn)
Ensembl ID	ENSG00000164485 (Hs), ENSMUSG00000039760 (Mm), ENSRNOG00000012259 (Rn)
UniProtKB AC	Q969J5 (Hs), Q80XF5 (Mm), Q7TNI4 (Rn)
Comment	Soluble decoy receptor that binds IL-22 (IL22, Q9GZX6) as a monomer.

Interleukin 10 receptor, α subunit C Show summary »« Hide summary More detailed page go icon to follow link

Interleukin 10 receptor, β subunit C Show summary »« Hide summary More detailed page go icon to follow link

Interleukin 20 receptor, α subunit C Show summary »« Hide summary More detailed page go icon to follow link

Interleukin 20 receptor, β subunit C Show summary »« Hide summary More detailed page go icon to follow link

Interleukin 22 receptor, α1 subunit C Show summary »« Hide summary More detailed page go icon to follow link

Interferon-λ receptor subunit 1 C Show summary »« Hide summary More detailed page go icon to follow link

References

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How to cite this family page

Database page citation:

IL-10 receptor family. Accessed on 08/04/2026. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=311.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Peach CJ, Gibb AJ, Kelly E, Mathie AA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Southan C, Davies JA et al. (2025) The Concise Guide to PHARMACOLOGY 2025/26: Catalytic receptors. Br J Pharmacol. 182: S259-S306.