GM-CSF receptor, α subunit | IL-3 receptor family | IUPHAR Guide to IMMUNOPHARMACOLOGY

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GM-CSF receptor, α subunit

  Target has curated data in GtoImmuPdb

Target id: 1707

Nomenclature: GM-CSF receptor, α subunit

Family: IL-3 receptor family

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

Quaternary Structure: Complexes
Granulocyte macrophage colony-stimulating factor receptor
Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 378 Xp22.32 and Yp11.3 CSF2RA colony stimulating factor 2 receptor alpha subunit
Mouse - 359 19 56.89 cM Csf2ra colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage)
Rat - - 14 Csf2ra colony stimulating factor 2 receptor alpha subunit
Previous and Unofficial Names
CD116 | granulocyte-macrophage colony stimulating receptor alpha | Csfgmra | CSF2R | colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage) | colony stimulating factor 2 receptor
Database Links
DrugBank Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
Natural/Endogenous Ligands
GM-CSF {Sp: Human}

Download all structure-activity data for this target as a CSV file

Key to terms and symbols Click column headers to sort
Antibody Sp. Action Value Parameter Reference
mavrilimumab Hs Binding 9.9 pIC50 1
pIC50 9.9 (IC50 1.39x10-10 M) [1]
Immunopharmacology Comments
This is the ligand binding subunit of the functional GM-CSF receptor complex.
Immuno Process Associations
Immuno Process:  Cytokine production & signalling
GO Annotations:  Associated to 4 GO processes, IEA only
GO:0004896 cytokine receptor activity IBA
GO:0004902 granulocyte colony-stimulating factor receptor activity IDA
GO:0019221 cytokine-mediated signaling pathway TAS
GO:0097011 cellular response to granulocyte macrophage colony-stimulating factor stimulus IDA
Clinically-Relevant Mutations and Pathophysiology
Disease:  Surfactant metabolism dysfunction, pulmonary, 4; SMDP4
Synonyms: Congenital pulmonary alveolar proteinosis [Orphanet: ORPHA264675]
Pulmonary alveolar proteinosis [Disease Ontology: DOID:12120]
Disease Ontology: DOID:12120
OMIM: 300770
Orphanet: ORPHA264675


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1. Cohen ES, Minter RR, Harrison PR, Sleeman MA, Nash AD, Fabri LJ. (2012) Antibody molecule for human GM-CSF receptor alpha. Patent number: US8263075. Assignee: Medimmune Limited. Priority date: 27/03/2006. Publication date: 11/09/2012.

How to cite this page

IL-3 receptor family: GM-CSF receptor, α subunit. Last modified on 22/03/2017. Accessed on 29/01/2020. IUPHAR/BPS Guide to PHARMACOLOGY,