Top ▲

GM-CSF receptor, α subunit

Click here for help

Immunopharmacology Ligand  Target has curated data in GtoImmuPdb

Target id: 1707

Nomenclature: GM-CSF receptor, α subunit

Family: IL-3 receptor family

Quaternary Structure: Complexes
Granulocyte macrophage colony-stimulating factor receptor
Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 400 Xp22.32 and Yp11.3 CSF2RA colony stimulating factor 2 receptor subunit alpha
Mouse 1 388 19 56.89 cM Csf2ra colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage)
Rat - - 14 Csf2ra colony stimulating factor 2 receptor subunit alpha
Previous and Unofficial Names Click here for help
CD116 | granulocyte-macrophage colony stimulating receptor alpha | Csfgmra | CSF2R | colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage) | colony stimulating factor 2 receptor | colony stimulating factor 2 receptor alpha subunit
Database Links Click here for help
Alphafold
CATH/Gene3D
ChEMBL Target
DrugBank Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
OMIM
Pharos
UniProtKB
Wikipedia
Natural/Endogenous Ligands Click here for help
GM-CSF {Sp: Human}

Download all structure-activity data for this target as a CSV file go icon to follow link

Antibodies
Key to terms and symbols Click column headers to sort
Antibody Sp. Action Value Parameter Reference
mavrilimumab Peptide Primary target of this compound Immunopharmacology Ligand Hs Binding 9.9 pIC50 1
pIC50 9.9 (IC50 1.39x10-10 M) [1]
Immunopharmacology Comments
This is the ligand binding subunit of the functional GM-CSF receptor complex.
Immuno Process Associations
Immuno Process:  Cytokine production & signalling
GO Annotations:  Associated to 4 GO processes, IEA only
GO:0004896 cytokine receptor activity IBA
GO:0004902 granulocyte colony-stimulating factor receptor activity IDA
GO:0019221 cytokine-mediated signaling pathway TAS
GO:0097011 cellular response to granulocyte macrophage colony-stimulating factor stimulus IDA
Clinically-Relevant Mutations and Pathophysiology Click here for help
Disease:  Surfactant metabolism dysfunction, pulmonary, 4; SMDP4
Synonyms: Congenital pulmonary alveolar proteinosis [Orphanet: ORPHA264675]
Pulmonary alveolar proteinosis [Disease Ontology: DOID:12120]
Disease Ontology: DOID:12120
OMIM: 300770
Orphanet: ORPHA264675

References

Show »

1. Cohen ES, Minter RR, Harrison PR, Sleeman MA, Nash AD, Fabri LJ. (2012) Antibody molecule for human GM-CSF receptor alpha. Patent number: US8263075. Assignee: Medimmune Limited. Priority date: 27/03/2006. Publication date: 11/09/2012.

How to cite this page

IL-3 receptor family: GM-CSF receptor, α subunit. Last modified on 22/03/2017. Accessed on 01/12/2021. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetoimmunopharmacology.org/GRAC/ObjectDisplayForward?objectId=1707.