Interleukin-7 receptor subunit α | IL-2 receptor family | IUPHAR Guide to IMMUNOPHARMACOLOGY

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Interleukin-7 receptor subunit α

  Target has curated data in GtoImmuPdb

Target id: 1698

Nomenclature: Interleukin-7 receptor subunit α

Family: IL-2 receptor family

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

Quaternary Structure: Complexes
Interleukin-7 receptor
Thymic stromal lymphopoietin receptor
Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 459 05p13.2 IL7R interleukin 7 receptor
Mouse 1 459 Il7r interleukin 7 receptor
Rat - - Il7r interleukin 7 receptor
Previous and Unofficial Names
CD127 | interleukin-7 receptor subunit alpha | IL-7 receptor alpha chain
Database Links
CATH/Gene3D
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
OMIM
UniProtKB
Wikipedia

Download all structure-activity data for this target as a CSV file

Antibodies
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Antibody Sp. Action Affinity Parameter Reference
OSE-127 Hs Antagonist ~11.4 pEC50 3
pEC50 ~11.4 (EC50 ~4x10-12 M) [3]
Description: In an ELISA binding assay.
Immunopharmacology Comments
This is the ligand binding subunit of the functional IL-7 receptor complex.
Effimmune are developing anti-IL7Rα monoclonal antibodies (e.g. OSE-127 [3]) with the objective of suppressing inflammation in T cell-mediated chronic inflammatory diseases. This team have reported that anti-IL7Rα monoclonals with exclusively antagonistic activity are efficacious in a non-human primate chronic skin inflammation model, and that the response is characterised by a sustained blunting of antigen-specific memory T cell activity [1].
Cell Type Associations
Immuno Cell Type:  T cells
Cell Ontology Term:   effector T cell (CL:0000911)
Comment:  IL-7RA (CD127) is expressed on Teff cells, and is involved in the development and persistence of chronic colitis [5].
References:  2,4
Immuno Process Associations
Immuno Process:  Cytokine production & signalling
GO Annotations:  Associated to 3 GO processes
GO:0004896 cytokine receptor activity IDA
GO:0004917 interleukin-7 receptor activity TAS
GO:0038111 interleukin-7-mediated signaling pathway TAS
Immuno Process:  T cell (activation)
GO Annotations:  Associated to 4 GO processes, IEA only
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GO:0001915 negative regulation of T cell mediated cytotoxicity IEA
GO:0030217 T cell differentiation IEA
GO:0033089 positive regulation of T cell differentiation in thymus IEA
GO:0070233 negative regulation of T cell apoptotic process IEA
Immuno Process:  B cell (activation)
GO Annotations:  Associated to 2 GO processes, IEA only
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GO:0001915 negative regulation of T cell mediated cytotoxicity IEA
GO:0042100 B cell proliferation IEA
Immuno Process:  Immune regulation
GO Annotations:  Associated to 2 GO processes, IEA only
click arrow to show/hide IEA associations
GO:0001915 negative regulation of T cell mediated cytotoxicity IEA
GO:0033089 positive regulation of T cell differentiation in thymus IEA
Immuno Process:  Immune system development
GO Annotations:  Associated to 3 GO processes, IEA only
click arrow to show/hide IEA associations
GO:0030217 T cell differentiation IEA
GO:0033089 positive regulation of T cell differentiation in thymus IEA
GO:0048535 lymph node development IEA
Immuno Process:  Chemotaxis & migration
GO Annotations:  Associated to 1 GO processes, IEA only
click arrow to show/hide IEA associations
GO:0033089 positive regulation of T cell differentiation in thymus IEA
Immuno Process:  Cellular signalling
GO Annotations:  Associated to 3 GO processes, IEA only
click arrow to show/hide IEA associations
GO:0030217 T cell differentiation IEA
GO:0033089 positive regulation of T cell differentiation in thymus IEA
GO:0042100 B cell proliferation IEA

References

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1. Belarif L, Mary C, Jacquemont L, Mai HL, Danger R, Hervouet J, Minault D, Thepenier V, Nerrière-Daguin V, Nguyen E et al.. (2018) IL-7 receptor blockade blunts antigen-specific memory T cell responses and chronic inflammation in primates. Nat Commun, 9 (1): 4483. [PMID:30367166]

2. Liu W, Putnam AL, Xu-Yu Z, Szot GL, Lee MR, Zhu S, Gottlieb PA, Kapranov P, Gingeras TR, Fazekas de St Groth B et al.. (2006) CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+ T reg cells. J. Exp. Med., 203 (7): 1701-11. [PMID:16818678]

3. Poirier N, Mary C, Vanhove B. (2015) Antibodies directed against CD127. Patent number: WO2015189302. Assignee: Effimune. Priority date: 10/06/2014. Publication date: 17/12/2015.

4. Seddiki N, Santner-Nanan B, Martinson J, Zaunders J, Sasson S, Landay A, Solomon M, Selby W, Alexander SI, Nanan R et al.. (2006) Expression of interleukin (IL)-2 and IL-7 receptors discriminates between human regulatory and activated T cells. J. Exp. Med., 203 (7): 1693-700. [PMID:16818676]

5. Shinohara T, Nemoto Y, Kanai T, Kameyama K, Okamoto R, Tsuchiya K, Nakamura T, Totsuka T, Ikuta K, Watanabe M. (2011) Upregulated IL-7 receptor α expression on colitogenic memory CD4+ T cells may participate in the development and persistence of chronic colitis. J. Immunol., 186 (4): 2623-32. [PMID:21217010]

How to cite this page

IL-2 receptor family: Interleukin-7 receptor subunit α. Last modified on 29/10/2018. Accessed on 19/03/2019. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetoimmunopharmacology.org/GRAC/ObjectDisplayForward?objectId=1698.