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Interleukin-7 receptor subunit α

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Immunopharmacology Ligand  Target has curated data in GtoImmuPdb

Target id: 1698

Nomenclature: Interleukin-7 receptor subunit α

Family: IL-2 receptor family

Contents:

Quaternary Structure: Complexes
Interleukin-7 receptor
Thymic stromal lymphopoietin receptor
Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 459 5p13.2 IL7R interleukin 7 receptor
Mouse 1 459 15 4.16 cM Il7r interleukin 7 receptor
Rat - - Il7r interleukin 7 receptor
Previous and Unofficial Names Click here for help
CD127 | interleukin-7 receptor subunit alpha | IL-7 receptor alpha chain
Database Links Click here for help
Alphafold P16871 (Hs), P16872 (Mm)
CATH/Gene3D 2.60.40.10
Ensembl Gene ENSG00000168685 (Hs), ENSMUSG00000003882 (Mm), ENSRNOG00000065741 (Rn)
Entrez Gene 3575 (Hs), 16197 (Mm), 294797 (Rn)
Human Protein Atlas ENSG00000168685 (Hs)
KEGG Gene hsa:3575 (Hs), mmu:16197 (Mm), rno:294797 (Rn)
OMIM 146661 (Hs)
Pharos P16871 (Hs)
UniProtKB P16871 (Hs), P16872 (Mm)
Wikipedia IL7R (Hs)

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Antibodies
Key to terms and symbols Click column headers to sort
Antibody Sp. Action Value Parameter Reference
OSE-127 Peptide Primary target of this compound Immunopharmacology Ligand Hs Antagonist ~11.4 pEC50 3
⤷ pEC50 ~11.4 (EC50 ~4x10-12 M) [3]
Description: In an ELISA binding assay.
Immunopharmacology Comments
This is the ligand binding subunit of the functional IL-7 receptor complex.
Effimmune are developing anti-IL7Rα monoclonal antibodies (e.g. OSE-127 [3]) with the objective of suppressing inflammation in T cell-mediated chronic inflammatory diseases. This team have reported that anti-IL7Rα monoclonals with exclusively antagonistic activity are efficacious in a non-human primate chronic skin inflammation model, and that the response is characterised by a sustained blunting of antigen-specific memory T cell activity [1].
Cell Type Associations
Immuno Cell Type:  T cells
Cell Ontology Term:   effector T cell (CL:0000911)
Comment:  IL-7RA (CD127) is expressed on Teff cells, and is involved in the development and persistence of chronic colitis [5].
References:  2,4
Immuno Process Associations
Immuno Process:  Cytokine production & signalling
Immuno Process:  T cell (activation)
Immuno Process:  B cell (activation)
Immuno Process:  Immune regulation
Immuno Process:  Immune system development
Immuno Process:  Chemotaxis & migration
Immuno Process:  Cellular signalling

References

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1. Belarif L, Mary C, Jacquemont L, Mai HL, Danger R, Hervouet J, Minault D, Thepenier V, Nerrière-Daguin V, Nguyen E et al.. (2018) IL-7 receptor blockade blunts antigen-specific memory T cell responses and chronic inflammation in primates. Nat Commun, 9 (1): 4483. [PMID:30367166]

2. Liu W, Putnam AL, Xu-Yu Z, Szot GL, Lee MR, Zhu S, Gottlieb PA, Kapranov P, Gingeras TR, Fazekas de St Groth B et al.. (2006) CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+ T reg cells. J Exp Med, 203 (7): 1701-11. [PMID:16818678]

3. Poirier N, Mary C, Vanhove B. (2015) Antibodies directed against CD127. Patent number: WO2015189302. Assignee: Effimune. Priority date: 10/06/2014. Publication date: 17/12/2015.

4. Seddiki N, Santner-Nanan B, Martinson J, Zaunders J, Sasson S, Landay A, Solomon M, Selby W, Alexander SI, Nanan R et al.. (2006) Expression of interleukin (IL)-2 and IL-7 receptors discriminates between human regulatory and activated T cells. J Exp Med, 203 (7): 1693-700. [PMID:16818676]

5. Shinohara T, Nemoto Y, Kanai T, Kameyama K, Okamoto R, Tsuchiya K, Nakamura T, Totsuka T, Ikuta K, Watanabe M. (2011) Upregulated IL-7 receptor α expression on colitogenic memory CD4+ T cells may participate in the development and persistence of chronic colitis. J Immunol, 186 (4): 2623-32. [PMID:21217010]

How to cite this page

IL-2 receptor family: Interleukin-7 receptor subunit α. Last modified on 29/10/2018. Accessed on 11/10/2024. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetoimmunopharmacology.org/GRAC/ObjectDisplayForward?objectId=1698.