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Endoplasmic reticulum aminopeptidase 2

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Target not currently curated in GtoImmuPdb

Target id: 1567

Nomenclature: Endoplasmic reticulum aminopeptidase 2

Family: M1: Aminopeptidase N

Contents:

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 960 5q15 ERAP2 endoplasmic reticulum aminopeptidase 2
Previous and Unofficial Names Click here for help
L-RAP | Leukocyte-derived arginine aminopeptidase
Database Links Click here for help
Specialist databases
MEROPS M01.024 (Hs)
Other databases
Alphafold Q6P179 (Hs)
BRENDA 3.4.11.-
ChEMBL Target CHEMBL5043 (Hs)
Ensembl Gene ENSG00000164308 (Hs)
Entrez Gene 64167 (Hs)
Human Protein Atlas ENSG00000164308 (Hs)
KEGG Enzyme 3.4.11.-
KEGG Gene hsa:64167 (Hs)
OMIM 609497 (Hs)
Pharos Q6P179 (Hs)
RefSeq Nucleotide NM_001130140 (Hs), NM_022350 (Hs)
RefSeq Protein NP_001123612 (Hs), NP_071745 (Hs)
UniProtKB Q6P179 (Hs)
Wikipedia ERAP2 (Hs)
Enzyme Reaction Click here for help
EC Number: 3.4.11.-

Download all structure-activity data for this target as a CSV file go icon to follow link

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
compound 2g [PMID: 27390066] Small molecule or natural product Click here for species-specific activity table Immunopharmacology Ligand Hs Inhibition 6.8 pKi 2
⤷ pKi 6.8 (Ki 1.5x10-7 M) [2]
compound 3v [PMID: 27390066] Small molecule or natural product Primary target of this compound Click here for species-specific activity table Immunopharmacology Ligand Hs Inhibition 6.2 pKi 2
⤷ pKi 6.2 (Ki 6.2x10-7 M) [2]
compound 17 [PMID: 23916253] Small molecule or natural product Click here for species-specific activity table Hs Inhibition 5.1 pIC50 1
⤷ pIC50 5.1 (IC50 8.9x10-6 M) [1]
Immuno Process Associations
Immuno Process:  Antigen presentation
Immuno Process:  T cell (activation)
Immuno Process:  B cell (activation)

References

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1. Papakyriakou A, Zervoudi E, Theodorakis EA, Saveanu L, Stratikos E, Vourloumis D. (2013) Novel selective inhibitors of aminopeptidases that generate antigenic peptides. Bioorg Med Chem Lett, 23 (17): 4832-6. [PMID:23916253]

2. Węglarz-Tomczak E, Vassiliou S, Mucha A. (2016) Discovery of potent and selective inhibitors of human aminopeptidases ERAP1 and ERAP2 by screening libraries of phosphorus-containing amino acid and dipeptide analogues. Bioorg Med Chem Lett, 26 (16): 4122-6. [PMID:27390066]

How to cite this page

M1: Aminopeptidase N: Endoplasmic reticulum aminopeptidase 2. Last modified on 20/10/2017. Accessed on 18/04/2024. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetoimmunopharmacology.org/GRAC/ObjectDisplayForward?objectId=1567.