M1: Aminopeptidase N | Enzymes | IUPHAR/BPS Guide to IMMUNOPHARMACOLOGY

M1: Aminopeptidase N C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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Aminopeptidases catalyze the cleavage of amino acids from the amino (N) terminus of protein or peptide substrates, and are involved in many essential cellular functions. Members of this enzyme family may be monomeric or multi-subunit complexes, and many are zinc metalloenzymes [2].

Enzymes

Targets of relevance to immunopharmacology are highlighted in blue

Aminopeptidase N Show summary »« Hide summary More detailed page

Target Id

1560

Nomenclature

Aminopeptidase N

Previous and unofficial names

Genes

ANPEP (Hs), Anpep (Mm), Anpep (Rn)

Ensembl ID

ENSG00000166825 (Hs), ENSMUSG00000039062 (Mm), ENSRNOG00000014610 (Rn)

UniProtKB AC

P15144 (Hs), P97449 (Mm), P15684 (Rn)

EC number

3.4.11.2

Aminopeptidase O Show summary »« Hide summary

Aminopeptidase Q Show summary »« Hide summary

Target Id

1562

Nomenclature

Aminopeptidase Q

Previous and unofficial names

APQ | AQPEP

Genes

LVRN (Hs)

Ensembl ID

ENSG00000172901 (Hs)

UniProtKB AC

Q6Q4G3 (Hs)

EC number

3.4.11.-

Arginyl aminopeptidase Show summary »« Hide summary More detailed page

Arginyl aminopeptidase-like 1 Show summary »« Hide summary

Endoplasmic reticulum aminopeptidase 1 Show summary »« Hide summary More detailed page

Target Id

1566

Nomenclature

Endoplasmic reticulum aminopeptidase 1

Previous and unofficial names

Genes

ERAP1 (Hs), Erap1 (Mm), Erap1 (Rn)

Ensembl ID

ENSG00000164307 (Hs), ENSMUSG00000021583 (Mm), ENSRNOG00000009997 (Rn)

UniProtKB AC

Q9NZ08 (Hs), Q9EQH2 (Mm), Q9JJ22 (Rn)

EC number

3.4.11.-

Endoplasmic reticulum aminopeptidase 2 Show summary »« Hide summary More detailed page

Target Id

1567

Nomenclature

Endoplasmic reticulum aminopeptidase 2

Previous and unofficial names

L-RAP | Leukocyte-derived arginine aminopeptidase

Genes

ERAP2 (Hs)

Ensembl ID

ENSG00000164308 (Hs)

UniProtKB AC

Q6P179 (Hs)

EC number

3.4.11.-

Glutamyl aminopeptidase Show summary »« Hide summary More detailed page

Target Id

1568

Nomenclature

Glutamyl aminopeptidase

Previous and unofficial names

differentiation antigen gp160 | EAP | APA | Ly51 | CD249 | gp160 | glutamyl aminopeptidase (aminopeptidase A)

Genes

ENPEP (Hs), Enpep (Mm), Enpep (Rn)

Ensembl ID

ENSG00000138792 (Hs), ENSMUSG00000028024 (Mm), ENSRNOG00000030121 (Rn)

UniProtKB AC

Q07075 (Hs), P16406 (Mm), P50123 (Rn)

EC number

3.4.11.7

Leucyl-cysteinyl aminopeptidase Show summary »« Hide summary More detailed page

Leukotriene A₄ hydrolase C Show summary »« Hide summary More detailed page

Puromycin-sensitive aminopeptidase Show summary »« Hide summary More detailed page

TRH-specific aminopeptidase Show summary »« Hide summary

Target Id

1577

Nomenclature

TRH-specific aminopeptidase

Previous and unofficial names

Genes

TRHDE (Hs), Trhde (Mm), Trhde (Rn)

Ensembl ID

ENSG00000072657 (Hs), ENSMUSG00000050663 (Mm), ENSRNOG00000005278 (Rn)

UniProtKB AC

Q9UKU6 (Hs), Q8K093 (Mm), Q10836 (Rn)

EC number

3.4.19.6

References

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How to cite this family page

Database page citation:

M1: Aminopeptidase N. Accessed on 22/08/2019. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=737.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Marrion NV, Peters JA, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators. (2017) The Concise Guide to PHARMACOLOGY 2017/18: Enzymes. Br J Pharmacol. 174 Suppl 1: S272-S359.