M1: Aminopeptidase N | Enzymes | IUPHAR/BPS Guide to IMMUNOPHARMACOLOGY

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M1: Aminopeptidase N C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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Aminopeptidases catalyze the cleavage of amino acids from the amino (N) terminus of protein or peptide substrates, and are involved in many essential cellular functions. Members of this enzyme family may be monomeric or multi-subunit complexes, and many are zinc metalloenzymes [3].

Enzymes

Targets of relevance to immunopharmacology are highlighted in blue

Aminopeptidase N Show summary »« Hide summary More detailed page go icon to follow link

Target Id

1560

Nomenclature

Aminopeptidase N

Previous and unofficial names

Genes

ANPEP (Hs), Anpep (Mm), Anpep (Rn)

Ensembl ID

ENSG00000166825 (Hs), ENSMUSG00000039062 (Mm), ENSRNOG00000014610 (Rn)

UniProtKB AC

P15144 (Hs), P97449 (Mm), P15684 (Rn)

EC number

3.4.11.2

Comment

APN has been identified as a receptor for the human coronavirus (HCoV) serotype 229E [4]. APN is engaged by a receptor-binding domain that is located between amino acids 417 and 547 of the viral spike glycoprotein [1]. HCoV-229E is a cause of the common cold.

Aminopeptidase O Show summary »« Hide summary

Aminopeptidase Q Show summary »« Hide summary

Target Id

1562

Nomenclature

Aminopeptidase Q

Previous and unofficial names

APQ | AQPEP

Genes

LVRN (Hs)

Ensembl ID

ENSG00000172901 (Hs)

UniProtKB AC

Q6Q4G3 (Hs)

EC number

3.4.11.-

Arginyl aminopeptidase Show summary »« Hide summary More detailed page go icon to follow link

Arginyl aminopeptidase-like 1 Show summary »« Hide summary

Endoplasmic reticulum aminopeptidase 1 Show summary »« Hide summary More detailed page go icon to follow link

Target Id

1566

Nomenclature

Endoplasmic reticulum aminopeptidase 1

Previous and unofficial names

Genes

ERAP1 (Hs), Erap1 (Mm), Erap1 (Rn)

Ensembl ID

ENSG00000164307 (Hs), ENSMUSG00000021583 (Mm), ENSRNOG00000009997 (Rn)

UniProtKB AC

Q9NZ08 (Hs), Q9EQH2 (Mm), Q9JJ22 (Rn)

EC number

3.4.11.-

Endoplasmic reticulum aminopeptidase 2 Show summary »« Hide summary More detailed page go icon to follow link

Target Id

1567

Nomenclature

Endoplasmic reticulum aminopeptidase 2

Previous and unofficial names

L-RAP | Leukocyte-derived arginine aminopeptidase

Genes

ERAP2 (Hs)

Ensembl ID

ENSG00000164308 (Hs)

UniProtKB AC

Q6P179 (Hs)

EC number

3.4.11.-

Glutamyl aminopeptidase Show summary »« Hide summary More detailed page go icon to follow link

Target Id

1568

Nomenclature

Glutamyl aminopeptidase

Previous and unofficial names

differentiation antigen gp160 | EAP | APA | Ly51 | CD249 | gp160 | glutamyl aminopeptidase (aminopeptidase A)

Genes

ENPEP (Hs), Enpep (Mm), Enpep (Rn)

Ensembl ID

ENSG00000138792 (Hs), ENSMUSG00000028024 (Mm), ENSRNOG00000051854 (Rn)

UniProtKB AC

Q07075 (Hs), P16406 (Mm), P50123 (Rn)

EC number

3.4.11.7

Leucyl-cysteinyl aminopeptidase Show summary »« Hide summary More detailed page go icon to follow link

Leukotriene A₄ hydrolase C Show summary »« Hide summary More detailed page go icon to follow link

Puromycin-sensitive aminopeptidase Show summary »« Hide summary More detailed page go icon to follow link

TRH-specific aminopeptidase Show summary »« Hide summary

Target Id

1577

Nomenclature

TRH-specific aminopeptidase

Previous and unofficial names

Genes

TRHDE (Hs), Trhde (Mm), Trhde (Rn)

Ensembl ID

ENSG00000072657 (Hs), ENSMUSG00000050663 (Mm), ENSRNOG00000005278 (Rn)

UniProtKB AC

Q9UKU6 (Hs), Q8K093 (Mm), Q10836 (Rn)

EC number

3.4.19.6

References

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1. Bonavia A, Zelus BD, Wentworth DE, Talbot PJ, Holmes KV. (2003) Identification of a receptor-binding domain of the spike glycoprotein of human coronavirus HCoV-229E. J Virol, 77 (4): 2530-8. [PMID:12551991]

2. Orning L, Krivi G, Fitzpatrick FA. (1991) Leukotriene A4 hydrolase. Inhibition by bestatin and intrinsic aminopeptidase activity establish its functional resemblance to metallohydrolase enzymes. J Biol Chem, 266 (3): 1375-8. [PMID:1846352]

3. Taylor A. (1993) Aminopeptidases: structure and function. FASEB J, 7 (2): 290-8. [PMID:8440407]

4. Yeager CL, Ashmun RA, Williams RK, Cardellichio CB, Shapiro LH, Look AT, Holmes KV. (1992) Human aminopeptidase N is a receptor for human coronavirus 229E. Nature, 357 (6377): 420-2. [PMID:1350662]

How to cite this family page

Database page citation:

M1: Aminopeptidase N. Accessed on 02/07/2025. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=737.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Enzymes. Br J Pharmacol. 180 Suppl 2:S289-373.