Synonyms: BMS-986205 | BMS986205 | Compound 2 [PMID: 29531094] | Example 19 [US20160137652A1]
Compound class:
Synthetic organic
Comment: Linrodostat (BMS-986205) is a potent and selective, orally available indoleamine 2,3-dioxygenase 1 (IDO1) inhibitor [3], being investigated as an immuno-therapeutic for various malignancies. The INN for linrodostat specifies the (R) stereoisomer. The chemical structure is claimed as example 19 in Flexus Bioscience's patent US2016137652 [1] and the compound is being taken through clinical development by Bristol-Myers Squibb. Mechanistically, linrodostat competes with the heme cofactor for binding to the apo-form of the enzyme, and once bound prevents heme from rebinding [3].
|
|
Classification | |
Compound class | Synthetic organic |
IUPAC Name |
(2R)-N-(4-chlorophenyl)-2-[4-(6-fluoroquinolin-4-yl)cyclohexyl]propanamide |
International Nonproprietary Names | |
INN number | INN |
10894 | linrodostat |
Synonyms |
BMS-986205 | BMS986205 | Compound 2 [PMID: 29531094] | Example 19 [US20160137652A1] |
Database Links | |
GtoPdb PubChem SID | 348353666 |
PubChem CID | 121328278 |
Search Google for chemical match using the InChIKey | KRTIYQIPSAGSBP-KLAILNCOSA-N |
Search Google for chemicals with the same backbone | KRTIYQIPSAGSBP |
Search PubMed clinical trials | linrodostat |
Search PubMed titles | linrodostat |
Search PubMed titles/abstracts | linrodostat |
UniChem Compound Search for chemical match using the InChIKey | KRTIYQIPSAGSBP-KLAILNCOSA-N |
UniChem Connectivity Search for chemical match using the InChIKey | KRTIYQIPSAGSBP-KLAILNCOSA-N |