ICOS ligand   Click here for help

GtoPdb Ligand ID: 9593

Abbreviated name: CD275
Synonyms: B7 homolog 2 | B7-H2 | B7-related protein 1 | B7RP-1 | ICOS-L
Immunopharmacology Ligand
Comment: Endogenous ligand for ICOS [1] that is expressed on the surface of antigen presenting cells. Inhibiting the ICOS/ICOSL axis is predicted to provide anti-inflammatory activity applicable for the treatment of autoimmune diseases.
The ICOSL protein contains an immunoglobulin (Ig)-like domain that resembles the antibody variable domain, that has been coined the 'V-set domain'. The genes for all human V-set domain containing proteins are listed in HGNC gene group 590.
The anti-ICOSL monoclonal antibody MEDI5872 (AMG557) is being evaluated in Phase 2 clinical trial in patients with primary Sjögren's syndrome (NCT02334306). Phase 1 trials of the same biologic in systemic lupus erythematosus (SLE) and psoriasis were terminated.
Species: Human
Classification Click here for help
Compound class Endogenous peptide in human, mouse or rat
Ligand families/groups CD molecules (ligands)
Synonyms Click here for help
B7 homolog 2 | B7-H2 | B7-related protein 1 | B7RP-1 | ICOS-L
Gene/Precursor Click here for help
Gene symbol Gene name Species Precursor protein name Synonyms
ICOSLG inducible T cell costimulator ligand Human ICOS ligand isoform a precursor inducible T-cell costimulator ligand
Database Links Click here for help
Ensembl Gene ENSG00000160223 (Hs)
GtoPdb PubChem SID 340590224
Human Protein Atlas ENSG00000160223 (Hs)
OMIM 605717 (Hs)
UniProtKB O75144 (Hs)