etrolizumab   Click here for help

GtoPdb Ligand ID: 8407

Synonyms: PRO145223 | RG-7413 | RG7413 | rhuMAb Beta7
Immunopharmacology Ligand
Compound class: Antibody
Comment: Etrolizumab is a humanized monoclonal antibody targeting integrin receptors containing the ITGB7 (β7) subunit (namely α4β7 and αEβ7).
Peptide sequence information for this antibody is available from its IMGT/mAb-DB record. Peptide sequence matches indicate that US7528236 is the covering patent [4]. The likely candidate antibody clone is that designated hu504.32R.
Etrolizumab has a slightly different mechanism of action compared to the already approved ulcerative colitis biologic vedolizumab (Entyvio®), which targets only α4β7 integrin.
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Classification Click here for help
Compound class Antibody
International Nonproprietary Names Click here for help
INN number INN
9290 etrolizumab
Synonyms Click here for help
PRO145223 | RG-7413 | RG7413 | rhuMAb Beta7
Database Links Click here for help
Specialist databases
IMGT/mAb-DB 362
Other databases
GtoPdb PubChem SID 252166617
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