adapalene   Click here for help

GtoPdb Ligand ID: 5429

Synonyms: Differin®
Approved drug
adapalene is an approved drug (FDA (1996))
Compound class: Synthetic organic
Comment: Adapalene is a third-generation topical anti-acne retinoid.
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 2
Hydrogen bond donors 1
Rotatable bonds 4
Topological polar surface area 46.53
Molecular weight 412.2
XLogP 8.57
No. Lipinski's rules broken 1
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Canonical SMILES COc1ccc(cc1C12CC3CC(C2)CC(C1)C3)c1ccc2c(c1)ccc(c2)C(=O)O
Isomeric SMILES COc1ccc(cc1C12CC3CC(C2)CC(C1)C3)c1ccc2c(c1)ccc(c2)C(=O)O
InChI InChI=1S/C28H28O3/c1-31-26-7-6-23(21-2-3-22-12-24(27(29)30)5-4-20(22)11-21)13-25(26)28-14-17-8-18(15-28)10-19(9-17)16-28/h2-7,11-13,17-19H,8-10,14-16H2,1H3,(H,29,30)
Classification Click here for help
Compound class Synthetic organic
Approved drug? Yes (FDA (1996))
IUPAC Name Click here for help
6-[3-(adamantan-1-yl)-4-methoxyphenyl]naphthalene-2-carboxylic acid
International Nonproprietary Names Click here for help
INN number INN
6675 adapalene
Synonyms Click here for help
Database Links Click here for help
CAS Registry No. 106685-40-9
ChEMBL Ligand CHEMBL1265
DrugBank Ligand DB00210
DrugCentral Ligand 87
GtoPdb PubChem SID 178102082
PubChem CID 60164
Search Google for chemical match using the InChIKey LZCDAPDGXCYOEH-UHFFFAOYSA-N
Search Google for chemicals with the same backbone LZCDAPDGXCYOEH
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UniChem Compound Search for chemical match using the InChIKey LZCDAPDGXCYOEH-UHFFFAOYSA-N
UniChem Connectivity Search for chemical match using the InChIKey LZCDAPDGXCYOEH-UHFFFAOYSA-N
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Adapalene (links to external site)
Cat. No. 2852