Synonyms: DNL-758 | DNL758 | example 42 [WO2017136727A2] | SAR443122
Compound class:
Synthetic organic
Comment: This chemical structure for eclitasertib (as the IUPAC name) was obtained from the special release of proposed INNs for COVID-related therapeutics that was published by the WHO in October 2020. The INN structure was identified as being identical to example 42 from Denali Therapeutics' patent WO2017136727A2. Denali claim this compound as a kinase inhibitor, and the INN application refers to it as a RIP kinase inhibitor. Based on Denali's initiation of their RIPK1 inhibitor DNL758 (a.k.a. SAR443122) in clinical trial in COVID-19 patients, we speculate that example 42, DNL758/SAR443122 and eclitasertib are one and the same. We will update this record when name>structure is formally disclosed.
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Classification ![]() |
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Compound class | Synthetic organic |
IUPAC Name ![]() |
5-benzyl-N-[(3S)-5-methyl-4-oxo-2,3-dihydropyrido[3,2-b][1,4]oxazepin-3-yl]-1H-1,2,4-triazole-3-carboxamide |
International Nonproprietary Names ![]() |
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INN number | INN |
11844 | eclitasertib |
Synonyms ![]() |
DNL-758 | DNL758 | example 42 [WO2017136727A2] | SAR443122 |
Database Links ![]() |
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BindingDB Ligand | 356271 |
CAS Registry No. | 2125450-76-0 (source: WHO INN record) |
ChEMBL Ligand | CHEMBL4861471 |
GtoPdb PubChem SID | 434321743 |
PubChem CID | 130298939 |
Search Google for chemical match using the InChIKey | XUZICJHIIJCKQQ-ZDUSSCGKSA-N |
Search Google for chemicals with the same backbone | XUZICJHIIJCKQQ |
Search PubMed clinical trials | eclitasertib |
Search PubMed titles | eclitasertib |
Search PubMed titles/abstracts | eclitasertib |
UniChem Compound Search for chemical match using the InChIKey | XUZICJHIIJCKQQ-ZDUSSCGKSA-N |
UniChem Connectivity Search for chemical match using the InChIKey | XUZICJHIIJCKQQ-ZDUSSCGKSA-N |
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Eclitasertib (links to external site)
Cat. No. HY-114371 |