casein kinase II inhibitor III   Click here for help

GtoPdb Ligand ID: 5941

Synonyms: TBCA | tetrabromocinnamic acid
Compound class: Synthetic organic
Comment: TBCA is a selective, cell-permeable inhibitor of casein kinase 2 (CK2) and has minimal effect on a panel of 28 other kinases [3].
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 2
Hydrogen bond donors 1
Rotatable bonds 2
Topological polar surface area 37.3
Molecular weight 459.69
XLogP 5.1
No. Lipinski's rules broken 1
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Canonical SMILES OC(=O)C=Cc1cc(Br)c(c(c1Br)Br)Br
Isomeric SMILES OC(=O)/C=C/c1cc(Br)c(c(c1Br)Br)Br
InChI InChI=1S/C9H4Br4O2/c10-5-3-4(1-2-6(14)15)7(11)9(13)8(5)12/h1-3H,(H,14,15)/b2-1+

Large-scale screening data

EMD Millipore KinaseProfilerTM screen/Reaction Biology Kinase HotspotSM screen Click here for help
A screen profiling 158 kinase inhibitors (Calbiochem Protein Kinase Inhibitor Library I and II, catalogue numbers 539744 and 539745) for their inhibitory activity at 1µM and 10µM against 234 human recombinant kinases using the EMD Millipore KinaseProfilerTM service.

A screen profiling the inhibitory activity of 178 commercially available kinase inhibitors at 0.5µM against a panel of 300 recombinant protein kinases using the Reaction Biology Corporation Kinase HotspotSM platform.

Reference: 1-2

Key to terms and symbols Click column headers to sort
Target Name in screen Sp. Type Action % Activity remaining at 0.5µM % Activity remaining at 1µM % Activity remaining at 10µM
casein kinase 2, alpha 1 polypeptide subunit CK2/CK2a Hs Inhibitor Inhibition 13.1 12.0 -8.0
Pim-1 proto-oncogene, serine/threonine kinase Pim-1/PIM1 Hs Inhibitor Inhibition 16.2 49.0 6.0
casein kinase 2, alpha prime polypeptide subunit CK2α2/CK2a2 Hs Inhibitor Inhibition 17.0 33.0 5.0
Pim-3 proto-oncogene, serine/threonine kinase Pim-3/PIM3 Hs Inhibitor Inhibition 17.7 78.0 39.0
PAS domain containing serine/threonine kinase PASK/PASK Hs Inhibitor Inhibition 24.8 63.0 6.0
ribosomal protein S6 kinase A3 Rsk2/RSK2 Hs Inhibitor Inhibition 41.2 59.0 43.0
serine/threonine kinase 11 LKB1/LKB1 Hs Inhibitor Inhibition 42.8 93.0 38.0
CDC like kinase 4 nd/CLK4 Hs Inhibitor Inhibition 45.4
polo like kinase 2 Snk/PLK2 Hs Inhibitor Inhibition 51.5 39.0 25.0
Pim-2 proto-oncogene, serine/threonine kinase Pim-2/PIM2 Hs Inhibitor Inhibition 52.8 28.0 1.0
Displaying the top 10 targets  View all targets in screen »