difamilast   Click here for help

GtoPdb Ligand ID: 9776

Synonyms: example 352 [WO2007058338] | MM36 | Moizerto® | OPA-15406
Approved drug Immunopharmacology Ligand
difamilast is an approved drug (Japan (2021))
Compound class: Synthetic organic
Comment: Difamilast (OPA-15406) is a topical, selective, nonsteroidal PDE4 inhibitor that is being developed for the treatment of atopic dermatitis [1-3]. The chemical structure is claimed as example 352 in patent WO2007058338 [4].
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 3
Hydrogen bond donors 1
Rotatable bonds 11
Topological polar surface area 82.82
Molecular weight 446.17
XLogP 4.74
No. Lipinski's rules broken 0
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Canonical SMILES CCOc1ccccc1C(=O)NCc1coc(n1)c1ccc(c(c1)OC(C)C)OC(F)F
Isomeric SMILES CCOc1ccccc1C(=O)NCc1coc(n1)c1ccc(c(c1)OC(C)C)OC(F)F
InChI InChI=1S/C23H24F2N2O5/c1-4-29-18-8-6-5-7-17(18)21(28)26-12-16-13-30-22(27-16)15-9-10-19(32-23(24)25)20(11-15)31-14(2)3/h5-11,13-14,23H,4,12H2,1-3H3,(H,26,28)
1. Freitas E, Torres T. (2023)
New molecules for atopic dermatitis treatment beyond biological therapy.
Curr Opin Allergy Clin Immunol, 23 (3): 210-215. [PMID:37185825]
2. Hanifin JM, Ellis CN, Frieden IJ, Fölster-Holst R, Stein Gold LF, Secci A, Smith AJ, Zhao C, Kornyeyeva E, Eichenfield LF. (2016)
OPA-15406, a novel, topical, nonsteroidal, selective phosphodiesterase-4 (PDE4) inhibitor, in the treatment of adult and adolescent patients with mild to moderate atopic dermatitis (AD): A phase-II randomized, double-blind, placebo-controlled study.
J Am Acad Dermatol, 75 (2): 297-305. [PMID:27189825]
3. Hiyama H, Arichika N, Okada M, Koyama N, Tahara T, Haruta J. (2023)
Pharmacological Profile of Difamilast, a Novel Selective Phosphodiesterase 4 Inhibitor, for Topical Treatment of Atopic Dermatitis.
J Pharmacol Exp Ther, 386 (1): 45-55. [PMID:37041087]
4. Okada M, Kato M, Sato N, Uno T, Kitagaki H, Haruta J, Hiyama H, Shibata T. (2007)
Oxazole compound and pharmaceutical composition.
Patent number: WO2007058338. Assignee: Otsuka Pharmaceutical Co., Ltd.. Priority date: 24/05/2007. Publication date: 15/11/2005.
5. Saeki H, Imamura T, Yokota D, Tsubouchi H. (2022)
Difamilast Ointment in Japanese Adult and Pediatric Patients with Atopic Dermatitis: A Phase III, Long-Term, Open-Label Study.
Dermatol Ther (Heidelb), 12 (7): 1589-1601. [PMID:35716332]