Synonyms: 6-Shogaol | [6]-shogaol | trans-6-shogaol
Compound class:
Synthetic organic
Comment: Enexasogaol (6-Shogaol) is a bioactive phytochemical isolated from ginger (Zingiber officinale Roscoe). It has anti-inflammatory, analgesic and antioxidant properties [1-2,4-5].
Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
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References |
1. Ezzat SM, Ezzat MI, Okba MM, Menze ET, Abdel-Naim AB. (2018)
The hidden mechanism beyond ginger (Zingiber officinale Rosc.) potent in vivo and in vitro anti-inflammatory activity. J Ethnopharmacol, 214: 113-123. [PMID:29253614] |
2. Han Q, Yuan Q, Meng X, Huo J, Bao Y, Xie G. (2017)
6-Shogaol attenuates LPS-induced inflammation in BV2 microglia cells by activating PPAR-γ. Oncotarget, 8 (26): 42001-42006. [PMID:28410218] |
3. Hitomi S, Ono K, Terawaki K, Matsumoto C, Mizuno K, Yamaguchi K, Imai R, Omiya Y, Hattori T, Kase Y et al.. (2017)
[6]-gingerol and [6]-shogaol, active ingredients of the traditional Japanese medicine hangeshashinto, relief oral ulcerative mucositis-induced pain via action on Na+ channels. Pharmacol Res, 117: 288-302. [PMID:28043879] |
4. Xu Y, Bai L, Chen X, Li Y, Qin Y, Meng X, Zhang Q. (2018)
6-Shogaol ameliorates diabetic nephropathy through anti-inflammatory, hyperlipidemic, anti-oxidative activity in db/db mice. Biomed Pharmacother, 97: 633-641. [PMID:29101807] |
5. Zhang M, Xu C, Liu D, Han MK, Wang L, Merlin D. (2018)
Oral Delivery of Nanoparticles Loaded With Ginger Active Compound, 6-Shogaol, Attenuates Ulcerative Colitis and Promotes Wound Healing in a Murine Model of Ulcerative Colitis. J Crohns Colitis, 12 (2): 217-229. [PMID:28961808] |