dihydrexidine   Click here for help

GtoPdb Ligand ID: 9267

Synonyms: DAR 0100A | DAR-0100A | DAR0100A
Compound class: Synthetic organic
Comment: Dihydrexidine is a moderately selective full agonist at the dopamine D1 and D5 receptors. Currently undergoing clinical trials to assess its efficacy in improving the cognitive and working memory deficits in schizophrenia and schizotypal disorder. Results of a proof-of-principle study are reported in [2].
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 1
Hydrogen bond donors 3
Rotatable bonds 0
Topological polar surface area 52.49
Molecular weight 267.13
XLogP 2.46
No. Lipinski's rules broken 0
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Canonical SMILES Oc1cc2CCC3C(c2cc1O)c1ccccc1CN3
Isomeric SMILES Oc1cc2CC[C@H]3[C@H](c2cc1O)c1ccccc1CN3
InChI InChI=1S/C17H17NO2/c19-15-7-10-5-6-14-17(13(10)8-16(15)20)12-4-2-1-3-11(12)9-18-14/h1-4,7-8,14,17-20H,5-6,9H2/t14-,17-/m0/s1
1. Lovenberg TW, Brewster WK, Mottola DM, Lee RC, Riggs RM, Nichols DE, Lewis MH, Mailman RB. (1989)
Dihydrexidine, a novel selective high potency full dopamine D-1 receptor agonist.
Eur J Pharmacol, 166 (1): 111-3. [PMID:2572425]
2. Rosell DR, Zaluda LC, McClure MM, Perez-Rodriguez MM, Strike KS, Barch DM, Harvey PD, Girgis RR, Hazlett EA, Mailman RB et al.. (2015)
Effects of the D1 dopamine receptor agonist dihydrexidine (DAR-0100A) on working memory in schizotypal personality disorder.
Neuropsychopharmacology, 40 (2): 446-53. [PMID:25074637]