Synonyms: PRAX-944 | PRAX944 | Z 944 | Z-944
Compound class:
Synthetic organic
Comment: PRAX-944 (Z-944) is a T-type calcium channel blocker/inhibitor [2].
![]() Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
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References |
1. Matthews LG, Puryear CB, Correia SS, Srinivasan S, Belfort GM, Pan MK, Kuo SH. (2023)
T-type calcium channels as therapeutic targets in essential tremor and Parkinson's disease. Ann Clin Transl Neurol, 10 (4): 462-483. [PMID:36738196] |
2. Scott L, Puryear CB, Belfort GM, Raines S, Hughes ZA, Matthews LG, Ravina B, Wittmann M. (2022)
Translational Pharmacology of PRAX-944, a Novel T-Type Calcium Channel Blocker in Development for the Treatment of Essential Tremor. Mov Disord, 37 (6): 1193-1201. [PMID:35257414] |
3. Tringham E, Powell KL, Cain SM, Kuplast K, Mezeyova J, Weerapura M, Eduljee C, Jiang X, Smith P, Morrison JL et al.. (2012)
T-type calcium channel blockers that attenuate thalamic burst firing and suppress absence seizures. Sci Transl Med, 4 (121): 121ra19. [PMID:22344687] |