CCL13   Click here for help

GtoPdb Ligand ID: 770

Synonyms: monocyte chemotactic protein-4
Immunopharmacology Ligand
Compound class: Endogenous peptide in human, mouse or rat
Comment: CCL13 is a CC chemokine.
Species: Human
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species
References
1. Lüttichau HR, Clark-Lewis I, Jensen PØ, Moser C, Gerstoft J, Schwartz TW. (2003)
A highly selective CCR2 chemokine agonist encoded by human herpesvirus 6.
J Biol Chem, 278 (13): 10928-33. [PMID:12554737]
2. Morokata T, Suzuki K, Masunaga Y, Taguchi K, Morihira K, Sato I, Fujii M, Takizawa S, Torii Y, Yamamoto N et al.. (2006)
A novel, selective, and orally available antagonist for CC chemokine receptor 3.
J Pharmacol Exp Ther, 317 (1): 244-50. [PMID:16339911]
3. Ruffing N, Sullivan N, Sharmeen L, Sodroski J, Wu L. (1998)
CCR5 has an expanded ligand-binding repertoire and is the primary receptor used by MCP-2 on activated T cells.
Cell Immunol, 189 (2): 160-8. [PMID:9790730]
4. Uguccioni M, Mackay CR, Ochensberger B, Loetscher P, Rhis S, LaRosa GJ, Rao P, Ponath PD, Baggiolini M, Dahinden CA. (1997)
High expression of the chemokine receptor CCR3 in human blood basophils. Role in activation by eotaxin, MCP-4, and other chemokines.
J Clin Invest, 100 (5): 1137-43. [PMID:9276730]
5. Weng Y, Siciliano SJ, Waldburger KE, Sirotina-Meisher A, Staruch MJ, Daugherty BL, Gould SL, Springer MS, DeMartino JA. (1998)
Binding and functional properties of recombinant and endogenous CXCR3 chemokine receptors.
J Biol Chem, 273 (29): 18288-91. [PMID:9660793]