compound 19a [PMID: 24359159]   Click here for help

GtoPdb Ligand ID: 6977

Compound class: Synthetic organic
Comment: Compound 19a is a potent, orally bioavailable Jak2 inhibitor [1], although data from this article suggest that 19a is equipotent (IC50 <3nM) at JAK1 and JAK2, but with significantly lower affinity for JAK3 (IC50 220nM).
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 7
Hydrogen bond donors 3
Rotatable bonds 5
Topological polar surface area 109.23
Molecular weight 353.15
XLogP 1.84
No. Lipinski's rules broken 0
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Canonical SMILES Fc1cnc(nc1)C(Nc1nc(Nc2ncn(c2)C)c2c(n1)[nH]cc2)C
Isomeric SMILES Fc1cnc(nc1)[C@@H](Nc1nc(Nc2ncn(c2)C)c2c(n1)[nH]cc2)C
InChI InChI=1S/C16H16FN9/c1-9(13-19-5-10(17)6-20-13)22-16-24-14-11(3-4-18-14)15(25-16)23-12-7-26(2)8-21-12/h3-9H,1-2H3,(H3,18,22,23,24,25)/t9-/m0/s1
1. Su Q, Ioannidis S, Chuaqui C, Almeida L, Alimzhanov M, Bebernitz G, Bell K, Block M, Howard T, Huang S et al.. (2014)
Discovery of 1-methyl-1H-imidazole derivatives as potent Jak2 inhibitors.
J Med Chem, 57 (1): 144-58. [PMID:24359159]