PMX205   Click here for help

GtoPdb Ligand ID: 5762

Synonyms: PMX 205 | PMX-205
Immunopharmacology Ligand
Comment: PMX205 is potent, non-competitive and orally active C5a receptor peptide antagonist [4].
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1. Jain U, Woodruff T, Stadnyk A. (2013)
The C5a receptor antagonist PMX205 ameliorates experimentally induced colitis associated with increased IL-4 and IL-10.
Br J Pharmacol, 168 (2): 488-501. [PMID:22924972]
2. Li XX, Lee JD, Massey NL, Guan C, Robertson AAB, Clark RJ, Woodruff TM. (2020)
Pharmacological characterisation of small molecule C5aR1 inhibitors in human cells reveals biased activities for signalling and function.
Biochem Pharmacol, 180: 114156. [PMID:32682759]
3. March DR, Proctor LM, Stoermer MJ, Sbaglia R, Abbenante G, Reid RC, Woodruff TM, Wadi K, Paczkowski N, Tyndall JD et al.. (2004)
Potent cyclic antagonists of the complement C5a receptor on human polymorphonuclear leukocytes. Relationships between structures and activity.
Mol Pharmacol, 65 (4): 868-79. [PMID:15044616]
4. Staab EB, Sanderson SD, Wells SM, Poole JA. (2014)
Treatment with the C5a receptor/CD88 antagonist PMX205 reduces inflammation in a murine model of allergic asthma.
Int Immunopharmacol, 21 (2): 293-300. [PMID:24859057]