IL-4

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Ligands
IL-4 (Human)

GtoPdb Ligand ID: 4996

Synonyms: B-cell stimulatory factor 1 | binetrakin | interleukin-4 | pitrakinra

Compound class: Endogenous peptide in human, mouse or rat

Comment: IL-4 shares sequence and structural homology with IL-13.

Species: Human

References
1. Hart TK, Blackburn MN, Brigham-Burke M, Dede K, Al-Mahdi N, Zia-Amirhosseini P, Cook RM. (2002) Preclinical efficacy and safety of pascolizumab (SB 240683): a humanized anti-interleukin-4 antibody with therapeutic potential in asthma. Clin Exp Immunol, 130 (1): 93-100. [PMID:12296858]
2. Sokol CL, Barton GM, Farr AG, Medzhitov R. (2008) A mechanism for the initiation of allergen-induced T helper type 2 responses. Nat Immunol, 9 (3): 310-8. [PMID:18300366]
3. Zheng J, Chen D, Xu J, Ding X, Wu Y, Shen HC, Tan X. (2021) Small molecule approaches to treat autoimmune and inflammatory diseases (Part III): Targeting cytokines and cytokine receptor complexes. Bioorg Med Chem Lett, 48: 128229. [PMID:34214508]

References

1. Hart TK, Blackburn MN, Brigham-Burke M, Dede K, Al-Mahdi N, Zia-Amirhosseini P, Cook RM. (2002)
Preclinical efficacy and safety of pascolizumab (SB 240683): a humanized anti-interleukin-4 antibody with therapeutic potential in asthma.
Clin Exp Immunol, 130 (1): 93-100. [PMID:12296858]

2. Sokol CL, Barton GM, Farr AG, Medzhitov R. (2008)
A mechanism for the initiation of allergen-induced T helper type 2 responses.
Nat Immunol, 9 (3): 310-8. [PMID:18300366]

3. Zheng J, Chen D, Xu J, Ding X, Wu Y, Shen HC, Tan X. (2021)
Small molecule approaches to treat autoimmune and inflammatory diseases (Part III): Targeting cytokines and cytokine receptor complexes.
Bioorg Med Chem Lett, 48: 128229. [PMID:34214508]