M-CSF

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Ligands
M-CSF (Human)

GtoPdb Ligand ID: 4905

Synonyms: CSF-1 | lanimostim | macrophage-CSF

Compound class: Endogenous peptide in human, mouse or rat

Comment: M-CSF (CSF1) controls survival and differentiation of macrophages via activation of the CSF1 receptor (a receptor tyrosine kinase). The biologically active peptide is a homodimer or a heterodimer.
Pharmacological modulators of the CSF1/CSF1R axis, targeting tumour-associated macrophage (TAM) survival, are being developed for various solid tumour and hematological oncology indications as well as for autoimmune diseases.

Species: Human

Summary
Biological activity
Clinical data
References
Structure
Similar ligands
Immunopharmacology

References
1. Kavanaugh WM. (2007) Use of antibody to m-csf. Patent number: WO2007016240 A2. Assignee: Novartis Ag, Xoma Technology Ltd.. Priority date: 28/07/2005. Publication date: 08/02/2007.

References

1. Kavanaugh WM. (2007)
Use of antibody to m-csf.
Patent number: WO2007016240 A2. Assignee: Novartis Ag, Xoma Technology Ltd.. Priority date: 28/07/2005. Publication date: 08/02/2007.