Synonyms: [3H]-GlySar | tritiated glycylsarcosine
Compound class:
Synthetic organic
Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
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References |
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Interactions of the dipeptide ester prodrugs of acyclovir with the intestinal oligopeptide transporter: competitive inhibition of glycylsarcosine transport in human intestinal cell line-Caco-2. J Pharmacol Exp Ther, 304 (2): 781-91. [PMID:12538834] |
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PepT1-mediated epithelial transport of dipeptides and cephalexin is enhanced by luminal leptin in the small intestine. J Clin Invest, 108 (10): 1483-94. [PMID:11714740] |
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Correlation between epithelial cell permeability of cephalexin and expression of intestinal oligopeptide transporter. J Pharmacol Exp Ther, 299 (2): 575-82. [PMID:11602669] |
4. Covitz KM, Amidon GL, Sadée W. (1996)
Human dipeptide transporter, hPEPT1, stably transfected into Chinese hamster ovary cells. Pharm Res, 13 (11): 1631-4. [PMID:8956326] |
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5'-Amino acid esters of antiviral nucleosides, acyclovir, and AZT are absorbed by the intestinal PEPT1 peptide transporter. Pharm Res, 15 (8): 1154-9. [PMID:9706043] |
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Significance and regional dependency of peptide transporter (PEPT) 1 in the intestinal permeability of glycylsarcosine: in situ single-pass perfusion studies in wild-type and Pept1 knockout mice. Drug Metab Dispos, 38 (10): 1740-6. [PMID:20660104] |
7. Li M, Anderson GD, Phillips BR, Kong W, Shen DD, Wang J. (2006)
Interactions of amoxicillin and cefaclor with human renal organic anion and peptide transporters. Drug Metab Dispos, 34 (4): 547-55. [PMID:16434549] |
8. Lu X, Chan T, Xu C, Zhu L, Zhou QT, Roberts KD, Chan HK, Li J, Zhou F. (2016)
Human oligopeptide transporter 2 (PEPT2) mediates cellular uptake of polymyxins. J Antimicrob Chemother, 71 (2): 403-12. [PMID:26494147] |
9. Otter M, Oswald S, Siegmund W, Keiser M. (2017)
Effects of frequently used pharmaceutical excipients on the organic cation transporters 1-3 and peptide transporters 1/2 stably expressed in MDCKII cells. Eur J Pharm Biopharm, 112: 187-195. [PMID:27903454] |
10. Sala-Rabanal M, Loo DD, Hirayama BA, Turk E, Wright EM. (2006)
Molecular interactions between dipeptides, drugs and the human intestinal H+ -oligopeptide cotransporter hPEPT1. J Physiol (Lond.), 574 (Pt 1): 149-66. [PMID:16627568] |
11. Sala-Rabanal M, Loo DD, Hirayama BA, Wright EM. (2008)
Molecular mechanism of dipeptide and drug transport by the human renal H+/oligopeptide cotransporter hPEPT2. Am J Physiol Renal Physiol, 294 (6): F1422-32. [PMID:18367661] |
12. Song F, Hu Y, Jiang H, Smith DE. (2017)
Species Differences in Human and Rodent PEPT2-Mediated Transport of Glycylsarcosine and Cefadroxil in Pichia Pastoris Transformants. Drug Metab Dispos, 45 (2): 130-136. [PMID:27836942] |
13. Tai W, Chen Z, Cheng K. (2013)
Expression profile and functional activity of peptide transporters in prostate cancer cells. Mol Pharm, 10 (2): 477-87. [PMID:22950754] |