Compound class:
Synthetic organic
Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
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References |
1. Gunthorpe MJ, Lummis SC. (1999)
Diltiazem causes open channel block of recombinant 5-HT3 receptors. J Physiol (Lond.), 519 Pt 3: 713-22. [PMID:10457085] |
2. Hu XQ, Peoples RW. (2008)
The 5-HT3B subunit confers spontaneous channel opening and altered ligand properties of the 5-HT3 receptor. J Biol Chem, 283 (11): 6826-31. [PMID:18187416] |
3. Kooyman AR, van Hooft JA, Vijverberg HP. (1993)
5-Hydroxyindole slows desensitization of the 5-HT3 receptor-mediated ion current in N1E-115 neuroblastoma cells. Br J Pharmacol, 108 (2): 287-9. [PMID:7680589] |
4. van Hooft JA, van der Haar E, Vijverberg HP. (1997)
Allosteric potentiation of the 5-HT3 receptor-mediated ion current in N1E-115 neuroblastoma cells by 5-hydroxyindole and analogues. Neuropharmacology, 36 (4-5): 649-53. [PMID:9225290] |