Synonyms: AGU-654 | compound 44 [PMID: 39622054]
Compound class:
Synthetic organic
Comment: AGU654 is a small molecule inhibitor of the microsomal enzyme prostaglandin E2 synthase 1 (mPGES1; the primary producer of proinflammatory PGE2) [1]. It is proposed to reduce inflammation and inflammatory pain, via suppression of prostaglandin E2 synthesis.
![]() Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
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References |
1. Ergül AG, Jordan PM, Dahlke P, Bal NB, Olğaç A, Uludağ O, Werz O, Çalışkan B, Banoglu E. (2024)
Novel Benzimidazole Derivatives as Potent Inhibitors of Microsomal Prostaglandin E2 Synthase 1 for the Potential Treatment of Inflammation, Pain, and Fever. J Med Chem, [Epub ahead of print]. [PMID:39622054] |