Synonyms: AAD-2004 | AAD2004
Compound class:
Synthetic organic
Comment: Crisdesalazine (AAD-2004) is a microsomal prostaglandin E2 synthase-1 (mPGES-1) inhibitor. Structurally it is an aspirin derivative. Blocking mPGES-1 inhibits prostaglandin E2 (PGE2)-mediated inflammation [2]. Crisdesalazine also exhibits antioxidant activity (removing free radicals).
![]() Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
|
References |
1. Baek IS, Kim TK, Seo JS, Lee KW, Lee YA, Cho J, Gwag BJ, Han PL. (2013)
AAD-2004 Attenuates Progressive Neuronal Loss in the Brain of Tg-betaCTF99/B6 Mouse Model of Alzheimer Disease. Exp Neurobiol, 22 (1): 31-7. [PMID:23585720] |
2. Shin JH, Lee YA, Lee JK, Lee YB, Cho W, Im DS, Lee JH, Yun BS, Springer JE, Gwag BJ. (2012)
Concurrent blockade of free radical and microsomal prostaglandin E synthase-1-mediated PGE2 production improves safety and efficacy in a mouse model of amyotrophic lateral sclerosis. J Neurochem, 122 (5): 952-61. [PMID:22537108] |