iPep-SARS2-E

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Ligands
iPep-SARS2-E

GtoPdb Ligand ID: 13253

Synonyms: TAT-MY18-2ED [1]

Compound class: Peptide or derivative

Comment: This is a small cell-penetrating peptide that targets coronavirus envelope (E) protein [1]. The first 13 amino acids represent a sequence that facilitates membrane penetration. Amino acids 14-31 are derived from the N-terminal (and extraviral) region of E protein, with Glu7 and Glu8 replaced by Asp residues. Experimental evidence suggests that iPep-SARS2-E integrates into SARS-CoV-2 E protein oligomers and reduces the E-mediated channel current in HEK cells.

Summary
Biological activity
References
Structure

References
1. Bekdash R, Yoshida K, Nair MS, Qiu L, Ahdout J, Tsai HY, Uryu K, Soni RK, Huang Y, Ho DD et al.. (2024) Developing inhibitory peptides against SARS-CoV-2 envelope protein. PLoS Biol, 22 (3): e3002522. [PMID:38483887]

References

1. Bekdash R, Yoshida K, Nair MS, Qiu L, Ahdout J, Tsai HY, Uryu K, Soni RK, Huang Y, Ho DD et al.. (2024)
Developing inhibitory peptides against SARS-CoV-2 envelope protein.
PLoS Biol, 22 (3): e3002522. [PMID:38483887]