Synonyms: Cmpd-6 [PMID: 34580163]
Compound class:
Synthetic organic
Comment: This ligand acts as a positive allosteric modulator (PAM) of β2-adrenoceptor activity [1-2].
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References |
1. Ahn S, Pani B, Kahsai AW, Olsen EK, Husemoen G, Vestergaard M, Jin L, Zhao S, Wingler LM, Rambarat PK et al.. (2018)
Small-Molecule Positive Allosteric Modulators of the β2-Adrenoceptor Isolated from DNA-Encoded Libraries. Mol Pharmacol, 94 (2): 850-861. [PMID:29769246] |
2. Pani B, Ahn S, Rambarat PK, Vege S, Kahsai AW, Liu A, Valan BN, Staus DP, Costa T, Lefkowitz RJ. (2021)
Unique Positive Cooperativity Between the β-Arrestin-Biased β-Blocker Carvedilol and a Small Molecule Positive Allosteric Modulator of the β2-Adrenergic Receptor. Mol Pharmacol, 100 (5): 513-525. [PMID:34580163] |