Synonyms: compound 1 [PMID: 37843072]
Compound class:
Natural product
Comment: Aplithianine A is an alkaloid that was isolated from an Aplidium sp. marine tunicate. It has inhibitory activity at a number of serine/threonine kinases, including protein kinase A catalytic subunit PKAcα, and has been shown in complex with the DNAJB1-PRKACA oncogenic fusion protein by X-ray crystallography [1]. A synthetic route to produce aplithianine A was developed.
![]() Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
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References |
1. Du L, Wilson BAP, Li N, Shah R, Dalilian M, Wang D, Smith EA, Wamiru A, Goncharova EI, Zhang P et al.. (2023)
Discovery and Synthesis of a Naturally Derived Protein Kinase Inhibitor that Selectively Inhibits Distinct Classes of Serine/Threonine Kinases. J Nat Prod, 86 (10): 2283-2293. [PMID:37843072] |