Synonyms: CC-99282 | CC99282 | compound 1 [US20220324855]
Compound class:
Synthetic organic
Comment: Golcadomide (CC-99282) is an oral molecular glue that promotes degradation of IKZF1/3 transcription factors (Ikaros/Aiolos) by engaging the cereblon E3 ubiquitin ligase complex. Structurally golcadomide is a novel thalidomide analogue (known as a CELMoD/cereblon E3 ligase modulator). It has immunomodulatory actions, with enhanced antiproliferative and proapoptotic activities compared to lenalidomide. The chemical structure for golcadomide is claimed in several Celgene patents (e.g. US20220324855A1 [1]).
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References |
1. Anton MSC, Buchholz TJ, Lopez-Girona A, Narla RK, Pourdehnad M. (2022)
Methods of treating non-hodgkin lymphoma using 2-(2,6-dioxopiperidin-3-yl)-4-((2-fluoro-4-((3-morpholinoazetidin-1-yl)methyl)benzyl)amino)isoindoline-1,3-dione. Patent number: US20220324855A1. Assignee: Celgene Corporation. Priority date: 24/06/2022. Publication date: 13/10/2022. |
2. Fuchs O. (2023)
Targeting cereblon in hematologic malignancies. Blood Rev, 57: 100994. [PMID:35933246] |