Synonyms: compound 4 [PMID: 32550990] [1] | TDRL551
Compound class:
Synthetic organic
Comment: TDRL-551 is a small molecule that was desigend by NERx BioSciences to block the interaction between replication protein A (RPA) and single stranded DNA, as a mechanism to enhance the efficacy of platinum-containing chemotherapy drugs [1].
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References |
1. Gavande NS, VanderVere-Carozza PS, Pawelczak KS, Vernon TL, Jordan MR, Turchi JJ. (2020)
Structure-Guided Optimization of Replication Protein A (RPA)-DNA Interaction Inhibitors. ACS Med Chem Lett, 11 (6): 1118-1124. [PMID:32550990] |