Synonyms: JTV803
Compound class:
Synthetic organic
Comment: JTV-803 is a small molecule, selective and direct inhibitor of Factor Xa [2]. It inhibits thrombus formation in in vivo models [1,3]. It is generally used as the mesylate salt.
Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
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References |
1. Asakura H, Ichino T, Yoshida T, Suga Y, Ontachi Y, Mizutani T, Kato M, Ito T, Yamazaki M, Aoshima K et al.. (2002)
Beneficial effect of JTV-803, a new synthetic inhibitor of activated factor X, against both lipopolysaccharide-induced and tissue factor-induced disseminated intravascular coagulation in rat models. Blood Coagul Fibrinolysis, 13 (3): 233-9. [PMID:11943937] |
2. Hayashi M, Hamada A, Okaya Y, Wakitani K, Aisaka K. (2001)
Inhibitory effect of JTV-803, a new cyclic guanidine derivative, on factor Xa in vitro and in vivo. Eur J Pharmacol, 428 (2): 163-8. [PMID:11675032] |
3. Hayashi M, Matsuo A, Nakamoto H, Aisaka K. (2001)
Antithrombotic effects of a synthetic inhibitor of activated factor X, JTV-803, in animals. Eur J Pharmacol, 412 (1): 61-6. [PMID:11166737] |
4. Ieko M, Tarumi T, Takeda M, Naito S, Nakabayashi T, Koike T. (2004)
Synthetic selective inhibitors of coagulation factor Xa strongly inhibit thrombin generation without affecting initial thrombin forming time necessary for platelet activation in hemostasis. J Thromb Haemost, 2 (4): 612-8. [PMID:15102016] |