Synonyms: decanoyl-Arg-Val-Lys-Arg-CMK | Decanoyl-RVKR-CMK
Compound class:
Synthetic organic
Comment: Decanoyl-RVKR-CMK is a cell‐permeable and irreversible inhibitor of proprotein convertase (PC) enzymes [2]. The PC family of serine proteases includes furin. Furin-mediated cleavage of HIV-1 envelope glycoprotein 160 (gp160) is essential for fusion of the viral envelope with the host cell membrane [2].
SARS-CoV-2: Decanoyl-RVKR-CMK inhibits cleavage of SARS-CoV-2 spike protein by furin, at the furin cleavage site, and this translates to an antiviral effect in vitro [1]. |
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References |
1. Cheng Y-W, Chao T-L, Li C-L, Chen P-J, Chang S-Y, Yeh S-H. (2020)
Furin Inhibitors Block SARS-CoV-2 Spike Protein Cleavage to Suppress Virus Production and Cytopathic Effects. Cell Reports, [Epub ahead of print]. DOI: 10.1016/j.celrep.2020.108254 |
2. Hallenberger S, Bosch V, Angliker H, Shaw E, Klenk HD, Garten W. (1992)
Inhibition of furin-mediated cleavage activation of HIV-1 glycoprotein gp160. Nature, 360 (6402): 358-61. [PMID:1360148] |