[125I]-HPP-icatibant   Click here for help

GtoPdb Ligand ID: 11158

Synonyms: [(125)I]-HPP-Hoe 140 | [125I]3-4 hydroxyphenyl-propionyl-D-Arg[Hyp3, Thi5, D-Tic7, Oic8]-BK | [125I]3-4 hydroxyphenyl-propionyl-D-Arg[Hyp3, Thi5, D-Tic7, Oic8]-bradykinin | [125I]3-4 hydroxyphenyl-propionyl-icatibant
 Ligand is labelled  Ligand is radioactive
Compound class: Peptide or derivative
Comment: This is a radiolabelled analogue of the B2 receptor antagonist icatibant [1-2]. It can be used for receptor autoradiography and radioligand binding assays.
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species
References
1. Cloutier F, de Sousa Buck H, Ongali B, Couture R. (2002)
Pharmacologic and autoradiographic evidence for an up-regulation of kinin B(2) receptors in the spinal cord of spontaneously hypertensive rats.
Br J Pharmacol, 135 (7): 1641-54. [PMID:11934804]
2. Cloutier F, Ongali B, Campos MM, Thibault G, Neugebauer W, Couture R. (2004)
Correlation between brain bradykinin receptor binding sites and cardiovascular function in young and adult spontaneously hypertensive rats.
Br J Pharmacol, 142 (2): 285-96. [PMID:15066903]