ghrelin   Click here for help

GtoPdb Ligand ID: 1099

Comment: There is some ambiguity in the literature and on other resources as to the exact chemical structure and stereochemistry of ghrelin. In the absence of a consensus chemical structure, we have chosen not to include an image of the molecule on this ligand entry. However, for representations of the structure please see these CHEBI:75431, CHEMBL425281 and PubChem CID 16133832 entries.
Species: Human
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View more information in the IUPHAR Pharmacology Education Project: ghrelin

1. Bedendi I, Alloatti G, Marcantoni A, Malan D, Catapano F, Ghé C, Deghenghi R, Ghigo E, Muccioli G. (2003)
Cardiac effects of ghrelin and its endogenous derivatives des-octanoyl ghrelin and des-Gln14-ghrelin.
Eur J Pharmacol, 476 (1-2): 87-95. [PMID:12969753]
2. Ge X, Yang H, Bednarek MA, Galon-Tilleman H, Chen P, Chen M, Lichtman JS, Wang Y, Dalmas O, Yin Y et al.. (2018)
LEAP2 Is an Endogenous Antagonist of the Ghrelin Receptor.
Cell Metab, 27 (2): 461-469.e6. [PMID:29233536]
3. Holst B, Brandt E, Bach A, Heding A, Schwartz TW. (2005)
Nonpeptide and peptide growth hormone secretagogues act both as ghrelin receptor agonist and as positive or negative allosteric modulators of ghrelin signaling.
Mol Endocrinol, 19 (9): 2400-11. [PMID:15905359]
4. Holst B, Cygankiewicz A, Jensen TH, Ankersen M, Schwartz TW. (2003)
High constitutive signaling of the ghrelin receptor--identification of a potent inverse agonist.
Mol Endocrinol, 17 (11): 2201-10. [PMID:12907757]
5. Matsumoto M, Hosoda H, Kitajima Y, Morozumi N, Minamitake Y, Tanaka S, Matsuo H, Kojima M, Hayashi Y, Kangawa K. (2001)
Structure-activity relationship of ghrelin: pharmacological study of ghrelin peptides.
Biochem Biophys Res Commun, 287 (1): 142-6. [PMID:11549267]
6. Muccioli G, Papotti M, Locatelli V, Ghigo E, Deghenghi R. (2001)
Binding of 125I-labeled ghrelin to membranes from human hypothalamus and pituitary gland.
J Endocrinol Invest, 24 (3): RC7-9. [PMID:11314756]
7. Palyha OC, Feighner SD, Tan CP, McKee KK, Hreniuk DL, Gao YD, Schleim KD, Yang L, Morriello GJ, Nargund R et al.. (2000)
Ligand activation domain of human orphan growth hormone (GH) secretagogue receptor (GHS-R) conserved from Pufferfish to humans.
Mol Endocrinol, 14 (1): 160-9. [PMID:10628755]
8. Sivertsen B, Lang M, Frimurer TM, Holliday ND, Bach A, Els S, Engelstoft MS, Petersen PS, Madsen AN, Schwartz TW et al.. (2011)
Unique interaction pattern for a functionally biased ghrelin receptor agonist.
J Biol Chem, 286 (23): 20845-60. [PMID:21402696]