Compound class:
Synthetic organic
Comment: NSC80734 is a small molecule protein-protein interaction inhibitor that disrupts human IL-18 binding to the ectromelia virus IL-18 binding protein (IL-18BP) [1]. IL-18BP acts as endogenous antagonist of IL-18 activity. By sequestering circulating IL-18 it modulates the amount of free IL-18 able to activate its receptor and downstream signalling cascade. NSC80734 binds in to the interaction site on IL-18 that engages IL-18BP, and thus it acts as an IL-18BP mimetic.
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References |
1. Krumm B, Meng X, Xiang Y, Deng J. (2017)
Identification of small molecule inhibitors of Interleukin-18. Sci Rep, 7 (1): 483. [PMID:28352119] |