WKYMVm   Click here for help

GtoPdb Ligand ID: 1048

Synonyms: Trp-Lys-Tyr-Met-Val-[D]Met | WKYMVM
Immunopharmacology Ligand
Compound class: Peptide
Comment: Peptide agonist of FPR1, FPR2 and FPR3 receptors.
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References
1. Bozinovski S, Anthony D, Anderson GP, Irving LB, Levy BD, Vlahos R. (2013)
Treating neutrophilic inflammation in COPD by targeting ALX/FPR2 resolution pathways.
Pharmacol Ther, 140 (3): 280-9. [PMID:23880288]
2. Christophe T, Karlsson A, Dugave C, Rabiet MJ, Boulay F, Dahlgren C. (2001)
The synthetic peptide Trp-Lys-Tyr-Met-Val-Met-NH2 specifically activates neutrophils through FPRL1/lipoxin A4 receptors and is an agonist for the orphan monocyte-expressed chemoattractant receptor FPRL2.
J Biol Chem, 276 (24): 21585-93. [PMID:11285256]
3. He HQ, Liao D, Wang ZG, Wang ZL, Zhou HC, Wang MW, Ye RD. (2013)
Functional characterization of three mouse formyl peptide receptors.
Mol Pharmacol, 83 (2): 389-98. [PMID:23160941]
4. He R, Tan L, Browning DD, Wang JM, Ye RD. (2000)
The synthetic peptide Trp-Lys-Tyr-Met-Val-D-Met is a potent chemotactic agonist for mouse formyl peptide receptor.
J Immunol, 165 (8): 4598-605. [PMID:11035102]
5. Le Y, Gong W, Li B, Dunlop NM, Shen W, Su SB, Ye RD, Wang JM. (1999)
Utilization of two seven-transmembrane, G protein-coupled receptors, formyl peptide receptor-like 1 and formyl peptide receptor, by the synthetic hexapeptide WKYMVm for human phagocyte activation.
J Immunol, 163 (12): 6777-84. [PMID:10586077]