WKYMVm   Click here for help

GtoPdb Ligand ID: 1048

Synonyms: Trp-Lys-Tyr-Met-Val-[D]Met | WKYMVM
Immunopharmacology Ligand
Compound class: Peptide or derivative
Comment: Peptide agonist of FPR1, FPR2 and FPR3 receptors.
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species
References
1. Bozinovski S, Anthony D, Anderson GP, Irving LB, Levy BD, Vlahos R. (2013)
Treating neutrophilic inflammation in COPD by targeting ALX/FPR2 resolution pathways.
Pharmacol Ther, 140 (3): 280-9. [PMID:23880288]
2. Christophe T, Karlsson A, Dugave C, Rabiet MJ, Boulay F, Dahlgren C. (2001)
The synthetic peptide Trp-Lys-Tyr-Met-Val-Met-NH2 specifically activates neutrophils through FPRL1/lipoxin A4 receptors and is an agonist for the orphan monocyte-expressed chemoattractant receptor FPRL2.
J Biol Chem, 276 (24): 21585-93. [PMID:11285256]
3. He HQ, Liao D, Wang ZG, Wang ZL, Zhou HC, Wang MW, Ye RD. (2013)
Functional characterization of three mouse formyl peptide receptors.
Mol Pharmacol, 83 (2): 389-98. [PMID:23160941]
4. He R, Tan L, Browning DD, Wang JM, Ye RD. (2000)
The synthetic peptide Trp-Lys-Tyr-Met-Val-D-Met is a potent chemotactic agonist for mouse formyl peptide receptor.
J Immunol, 165 (8): 4598-605. [PMID:11035102]
5. Le Y, Gong W, Li B, Dunlop NM, Shen W, Su SB, Ye RD, Wang JM. (1999)
Utilization of two seven-transmembrane, G protein-coupled receptors, formyl peptide receptor-like 1 and formyl peptide receptor, by the synthetic hexapeptide WKYMVm for human phagocyte activation.
J Immunol, 163 (12): 6777-84. [PMID:10586077]