Synonyms: Glanatec® | K-115 (ripasudil hydrochloride dihydrate)
ripasudil is an approved drug (Japan (2014))
Compound class:
Synthetic organic
Comment: Ripasudil is an isoquinoline class Rho-associated kinase (ROCK) inhibitor [1-2]. We present the parent molecule here. The hydrochloride dihydrate is referred to using the research code K-115 (see PubChem CID 11625386).
![]() Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
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References |
1. Garnock-Jones KP. (2014)
Ripasudil: first global approval. Drugs, 74 (18): 2211-5. [PMID:25414122] |
2. Isobe T, Mizuno K, Kaneko Y, Ohta M, Koide T, Tanabe S. (2014)
Effects of K-115, a rho-kinase inhibitor, on aqueous humor dynamics in rabbits. Curr Eye Res, 39 (8): 813-22. [PMID:24502505] |