Fz7-21   Click here for help

GtoPdb Ligand ID: 10324

Comment: Fz7-21 is a peptide antagonist of FZD7 [1]. It antagonises WNT3A-induced Wnt-β-catenin signalling in HEK293 expressing FZD7.
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1. Nile AH, de Sousa E Melo F, Mukund S, Piskol R, Hansen S, Zhou L, Zhang Y, Fu Y, Gogol EB, Kömüves LG et al.. (2018)
A selective peptide inhibitor of Frizzled 7 receptors disrupts intestinal stem cells.
Nat Chem Biol, 14 (6): 582-590. [PMID:29632413]