olinciguat   Click here for help

GtoPdb Ligand ID: 10213

Synonyms: IW-1701 | IW1701
Immunopharmacology Ligand
Compound class: Synthetic organic
Comment: olinciguat (IW-1701) is an orally bioavailable stimulator of (NO)-sensitive soluble guanylyl cyclase (sGC) [1] that is being developed by Ironwood Pharmaceuticals as a potential sickle cell disease therapeutic [2]. It acts as a cGMP amplifying agent.
2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the CDK toolkit. All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 7
Hydrogen bond donors 3
Rotatable bonds 9
Topological polar surface area 144.98
Molecular weight 509.12
XLogP 2.84
No. Lipinski's rules broken 0
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

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Canonical SMILES NC(=O)C(C(F)(F)F)(CNc1nc(ncc1F)c1nn(c(c1)c1nocc1)Cc1ccccc1F)O
Isomeric SMILES NC(=O)[C@@](C(F)(F)F)(CNc1nc(ncc1F)c1nn(c(c1)c1nocc1)Cc1ccccc1F)O
InChI InChI=1S/C21H16F5N7O3/c22-12-4-2-1-3-11(12)9-33-16(14-5-6-36-32-14)7-15(31-33)18-28-8-13(23)17(30-18)29-10-20(35,19(27)34)21(24,25)26/h1-8,35H,9-10H2,(H2,27,34)(H,28,29,30)/t20-/m1/s1
InChI Key YWQFJNWMWZMXRW-HXUWFJFHSA-N
References
1. Buys ES, Zimmer DP, Chickering J, Graul R, Chien YT, Profy A, Hadcock JR, Masferrer JL, Milne GT. (2018)
Discovery and development of next generation sGC stimulators with diverse multidimensional pharmacology and broad therapeutic potential.
Nitric Oxide, 78: 72-80. [PMID:29859918]
2. Ironwood Pharmaceuticals. 
Our Research & Development.
Accessed on 04/02/2019. Modified on 04/02/2019. www.ironwoodpharma.com, https://www.ironwoodpharma.com/research-and-development
3. Tchernychev B, Feil S, Germano P, Warren W, Lonie E, Feil R, MIlne TG, Hadcock J, Chien Y-T, Currie MG, Graul RM. (2017)
The Clinical-Stage sGC Stimulator IW-1701 Prevents Increase of Plasma Biomarkers of Intravascular Inflammation and Suppresses Leukocyte-Endothelial Interactions in Tnfα-Treated Mice.
Blood, 130: 447.